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An open multicentric trial was conducted on 175 patients to compare the antipyretic efficacy of ibuprofen (7 mg/kg) and paracetamol (8 mg/kg). Children between the age of 4 months and 12 years with fever were admitted to the study, 85 in the ibuprofen group and 90 in the paracetamol group. The axillary temperatures were recorded at half hourly intervals for 2 hours. The mean fall in temperature at 1, 1.5 and 2 hours was similar in both groups and the differences were not statistically significant (p greater than 0.05). At half hour, the fall in temperature (mean +/- SEM) for ibuprofen was 0.1975 +/- 0.0409 and for paracetamol was 0.3843 +/- 0.0490. This absolute difference of 0.19 degrees C was statistically significant (p less than 0.05). We conclude that ibuprofen has antipyretic activity comparable to that of paracetamol and that it could be a valuable alternative antipyretic in clinical practice. There is a need to repeat this trial with higher doses of ibuprofen, to establish a dose response of the drug, if any, and to find an optimally effective dose.
Y M Joshi, and
V B Sovani, and
V V Joshi, and
J R Navrange, and
D G Benakappa, and
P Shivananda, and
V S Sankaranarayanan
December 2000,
Indian journal of pediatrics,
Y M Joshi, and
V B Sovani, and
V V Joshi, and
J R Navrange, and
D G Benakappa, and
P Shivananda, and
V S Sankaranarayanan
February 2005,
Anales de pediatria (Barcelona, Spain : 2003),
Y M Joshi, and
V B Sovani, and
V V Joshi, and
J R Navrange, and
D G Benakappa, and
P Shivananda, and
V S Sankaranarayanan
January 1984,
The Journal of international medical research,
Y M Joshi, and
V B Sovani, and
V V Joshi, and
J R Navrange, and
D G Benakappa, and
P Shivananda, and
V S Sankaranarayanan
January 2014,
Perspectives in clinical research,
Y M Joshi, and
V B Sovani, and
V V Joshi, and
J R Navrange, and
D G Benakappa, and
P Shivananda, and
V S Sankaranarayanan
January 1980,
Journal of clinical pharmacology,
Y M Joshi, and
V B Sovani, and
V V Joshi, and
J R Navrange, and
D G Benakappa, and
P Shivananda, and
V S Sankaranarayanan
November 1997,
The Journal of pediatrics,
Y M Joshi, and
V B Sovani, and
V V Joshi, and
J R Navrange, and
D G Benakappa, and
P Shivananda, and
V S Sankaranarayanan
April 1985,
The British journal of clinical practice,
Y M Joshi, and
V B Sovani, and
V V Joshi, and
J R Navrange, and
D G Benakappa, and
P Shivananda, and
V S Sankaranarayanan
May 1992,
American journal of diseases of children (1960),
Y M Joshi, and
V B Sovani, and
V V Joshi, and
J R Navrange, and
D G Benakappa, and
P Shivananda, and
V S Sankaranarayanan
January 1985,
The British journal of clinical practice,
Y M Joshi, and
V B Sovani, and
V V Joshi, and
J R Navrange, and
D G Benakappa, and
P Shivananda, and
V S Sankaranarayanan
January 2004,
The Annals of pharmacotherapy,
