Maternal lead exposure during lactation persistently impairs testicular development and steroidogenesis in male offspring. 2013

Hua Wang, and Yan-Li Ji, and Qun Wang, and Xian-Feng Zhao, and Huan Ning, and Ping Liu, and Cheng Zhang, and Tao Yu, and Ying Zhang, and Xiu-Hong Meng, and De-Xiang Xu
Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230032, China.

Lead (Pb) is a testicular toxicant. In the present study, we investigated the effects of maternal Pb exposure during lactation on testicular development and steroidogenesis in male offspring. Maternal mice were exposed to different concentration of lead acetate (200 or 2000 ppm) through drinking water from postnatal day (PND) 0 to PND21. As expected, a high concentration of Pb was measured in the kidneys and liver of pups whose mothers were exposed to Pb during lactation. In addition, maternal Pb exposure during lactation elevated, to a less extent, Pb content in testes of weaning pups. Testis weight in weaning pups was significantly decreased when maternal mice were exposed to Pb during lactation. The level of serum and testicular T was reduced in Pb-exposed pups. The expression of P450scc, P450(17α) and 17β-HSD, key enzymes for T synthesis, was down-regulated in testes of weaning pups whose mothers were exposed to Pb during lactation. Interestingly, the level of serum and testicular T remained decreased in adult offspring whose mothers were exposed to Pb during lactation. Importantly, the number of spermatozoa was significantly reduced in Pb-exposed male offspring. Taken together, these results suggest that Pb could be transported from dams to pups through milk. Maternal Pb exposure during lactation persistently disrupts testicular development and steroidogenesis in male offspring.

UI MeSH Term Description Entries
D007774 Lactation The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN. Lactation, Prolonged,Milk Secretion,Lactations, Prolonged,Milk Secretions,Prolonged Lactation,Prolonged Lactations
D007854 Lead A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.
D008297 Male Males
D008815 Mice, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D008892 Milk The off-white liquid secreted by the mammary glands of humans and other mammals. It contains proteins, sugar, lipids, vitamins, and minerals. Cow Milk,Cow's Milk,Milk, Cow,Milk, Cow's
D009942 Organometallic Compounds A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed) Metallo-Organic Compound,Metallo-Organic Compounds,Metalloorganic Compound,Organometallic Compound,Metalloorganic Compounds,Compound, Metallo-Organic,Compound, Metalloorganic,Compound, Organometallic,Compounds, Metallo-Organic,Compounds, Metalloorganic,Compounds, Organometallic,Metallo Organic Compound,Metallo Organic Compounds
D002786 Cholesterol Side-Chain Cleavage Enzyme A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones. CYP11A1,Cholesterol Desmolase,Cholesterol Monooxygenase (Side-Chain-Cleaving),Cytochrome P-450 CYP11A1,Cytochrome P-450(scc),20,22-Desmolase,CYP 11A1,Cytochrome P450 11A1,Cytochrome P450scc,20,22 Desmolase,Cholesterol Side Chain Cleavage Enzyme,Cytochrome P 450 CYP11A1
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000831 Animals, Newborn Refers to animals in the period of time just after birth. Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals

Related Publications

Hua Wang, and Yan-Li Ji, and Qun Wang, and Xian-Feng Zhao, and Huan Ning, and Ping Liu, and Cheng Zhang, and Tao Yu, and Ying Zhang, and Xiu-Hong Meng, and De-Xiang Xu
January 2014, PloS one,
Hua Wang, and Yan-Li Ji, and Qun Wang, and Xian-Feng Zhao, and Huan Ning, and Ping Liu, and Cheng Zhang, and Tao Yu, and Ying Zhang, and Xiu-Hong Meng, and De-Xiang Xu
January 2014, PloS one,
Hua Wang, and Yan-Li Ji, and Qun Wang, and Xian-Feng Zhao, and Huan Ning, and Ping Liu, and Cheng Zhang, and Tao Yu, and Ying Zhang, and Xiu-Hong Meng, and De-Xiang Xu
April 2024, Ecotoxicology and environmental safety,
Hua Wang, and Yan-Li Ji, and Qun Wang, and Xian-Feng Zhao, and Huan Ning, and Ping Liu, and Cheng Zhang, and Tao Yu, and Ying Zhang, and Xiu-Hong Meng, and De-Xiang Xu
October 2020, Andrologia,
Hua Wang, and Yan-Li Ji, and Qun Wang, and Xian-Feng Zhao, and Huan Ning, and Ping Liu, and Cheng Zhang, and Tao Yu, and Ying Zhang, and Xiu-Hong Meng, and De-Xiang Xu
February 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Hua Wang, and Yan-Li Ji, and Qun Wang, and Xian-Feng Zhao, and Huan Ning, and Ping Liu, and Cheng Zhang, and Tao Yu, and Ying Zhang, and Xiu-Hong Meng, and De-Xiang Xu
May 2024, Ecotoxicology and environmental safety,
Hua Wang, and Yan-Li Ji, and Qun Wang, and Xian-Feng Zhao, and Huan Ning, and Ping Liu, and Cheng Zhang, and Tao Yu, and Ying Zhang, and Xiu-Hong Meng, and De-Xiang Xu
February 2020, Animals : an open access journal from MDPI,
Hua Wang, and Yan-Li Ji, and Qun Wang, and Xian-Feng Zhao, and Huan Ning, and Ping Liu, and Cheng Zhang, and Tao Yu, and Ying Zhang, and Xiu-Hong Meng, and De-Xiang Xu
May 2024, Ecotoxicology and environmental safety,
Hua Wang, and Yan-Li Ji, and Qun Wang, and Xian-Feng Zhao, and Huan Ning, and Ping Liu, and Cheng Zhang, and Tao Yu, and Ying Zhang, and Xiu-Hong Meng, and De-Xiang Xu
November 2014, Wei sheng yan jiu = Journal of hygiene research,
Hua Wang, and Yan-Li Ji, and Qun Wang, and Xian-Feng Zhao, and Huan Ning, and Ping Liu, and Cheng Zhang, and Tao Yu, and Ying Zhang, and Xiu-Hong Meng, and De-Xiang Xu
December 2009, The Journal of reproduction and development,
Copied contents to your clipboard!