-transparent.png){kind=logo}
The effect of the cholinergic agonist carbachol on a putative substrate for memory (long-term potentiation; LTP) was investigated in slices of rat hippocampus (CA1 region). Carbachol (5 microM) increased LTP when the presynaptic depression of the EPSP was controlled. The results indicate that carbachol enhances the effectiveness of the tetanus, probably through postsynaptic mechanisms. This effect may have implications for the role of acetylcholine in memory and the use of cholinergics in memory disorders.
Related Publications
R D Blitzer, and
O Gil, and
E M Landau
May 1998,
Experimental neurology,
R D Blitzer, and
O Gil, and
E M Landau
March 1991,
Brain research,
R D Blitzer, and
O Gil, and
E M Landau
January 1993,
Neuroscience,
R D Blitzer, and
O Gil, and
E M Landau
January 2002,
Hippocampus,
R D Blitzer, and
O Gil, and
E M Landau
August 2005,
Neuropharmacology,
R D Blitzer, and
O Gil, and
E M Landau
March 1996,
Science (New York, N.Y.),
R D Blitzer, and
O Gil, and
E M Landau
March 2001,
Brain research,
R D Blitzer, and
O Gil, and
E M Landau
March 1996,
Science (New York, N.Y.),
R D Blitzer, and
O Gil, and
E M Landau
February 2009,
European journal of pharmacology,
R D Blitzer, and
O Gil, and
E M Landau
November 2007,
Yao xue xue bao = Acta pharmaceutica Sinica,
