Magnetic and degradable polymer/bioactive glass composite nanoparticles for biomedical applications. 2013

A C Jayalekshmi, and Sunita Prem Victor, and Chandra P Sharma
Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Science and Technology, Thiruvananthapuram 695012, Kerala, India.

The present study focuses on the development of a biocompatible and biodegradable iron oxide incorporated chitosan-gelatin bioglass composite nanoparticles [Fe-BG]. The developed composite nanoparticle was analyzed by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, thermo gravimetric analysis (TG) and differential scanning calorimetry analysis (DSC). The size of the negatively charged composite nanoparticle was in the range of 43-51 nm. The in vitro analysis of the composite nanoparticles was carried out by cell aggregation, protein adsorption and haemolytic activity. The magnetic hysteresis value of the composite nanoparticle showed that it is a soft magnetic material. The presence of iron oxide in the chitosan-gelatin bioglass [BG] matrix enhances biodegradability as indicated in the TG studies. Iron-oxide in equal amount to bioglass in the polymer matrix has been obtained as the optimized system. The developed composite nanoparticle is a soft magnetic material and is suitable for the magnetic hyperthermia treatment and drug delivery. More detailed in vivo studies are needed to confirm the biodegradation profile and biological activity of the material.

UI MeSH Term Description Entries
D006979 Hyperthermia, Induced Abnormally high temperature intentionally induced in living things regionally or whole body. It is most often induced by radiation (heat waves, infra-red), ultrasound, or drugs. Fever Therapy,Hyperthermia, Local,Hyperthermia, Therapeutic,Thermotherapy,Induced Hyperthermia,Therapeutic Hyperthermia,Therapy, Fever,Local Hyperthermia
D008280 Magnetics The study of MAGNETIC PHENOMENA. Magnetic
D010974 Platelet Aggregation The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS. Aggregation, Platelet
D002152 Calorimetry, Differential Scanning Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample. Differential Thermal Analysis, Calorimetric,Calorimetric Differential Thermal Analysis,Differential Scanning Calorimetry,Scanning Calorimetry, Differential
D004563 Electrochemistry The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes. Electrochemistries
D004591 Electrophoresis, Polyacrylamide Gel Electrophoresis in which a polyacrylamide gel is used as the diffusion medium. Polyacrylamide Gel Electrophoresis,SDS-PAGE,Sodium Dodecyl Sulfate-PAGE,Gel Electrophoresis, Polyacrylamide,SDS PAGE,Sodium Dodecyl Sulfate PAGE,Sodium Dodecyl Sulfate-PAGEs
D004903 Erythrocyte Aggregation The formation of clumps of RED BLOOD CELLS under low or non-flow conditions, resulting from the attraction forces between the red blood cells. The cells adhere to each other in rouleaux aggregates. Slight mechanical force, such as occurs in the circulation, is enough to disperse these aggregates. Stronger or weaker than normal aggregation may result from a variety of effects in the ERYTHROCYTE MEMBRANE or in BLOOD PLASMA. The degree of aggregation is affected by ERYTHROCYTE DEFORMABILITY, erythrocyte membrane sialylation, masking of negative surface charge by plasma proteins, etc. BLOOD VISCOSITY and the ERYTHROCYTE SEDIMENTATION RATE are affected by the amount of erythrocyte aggregation and are parameters used to measure the aggregation. Erythrocyte Aggregation, Intravascular,Agglutination, Intravascular,Intravascular Agglutination,Intravascular Erythrocyte Aggregation,Rouleaux Formation, Erythrocyte,Agglutinations, Intravascular,Aggregation, Erythrocyte,Aggregation, Intravascular Erythrocyte,Aggregations, Erythrocyte,Aggregations, Intravascular Erythrocyte,Erythrocyte Aggregations,Erythrocyte Aggregations, Intravascular,Erythrocyte Rouleaux Formation,Erythrocyte Rouleaux Formations,Formation, Erythrocyte Rouleaux,Formations, Erythrocyte Rouleaux,Intravascular Agglutinations,Intravascular Erythrocyte Aggregations,Rouleaux Formations, Erythrocyte
D005290 Ferric Compounds Inorganic or organic compounds containing trivalent iron. Compounds, Ferric
D005898 Glass Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.
D006461 Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity. Haemolysis,Extravascular Hemolysis,Intravascular Hemolysis,Extravascular Hemolyses,Haemolyses,Hemolyses, Extravascular,Hemolyses, Intravascular,Hemolysis, Extravascular,Hemolysis, Intravascular,Intravascular Hemolyses

Related Publications

A C Jayalekshmi, and Sunita Prem Victor, and Chandra P Sharma
October 2012, Biomedical materials (Bristol, England),
A C Jayalekshmi, and Sunita Prem Victor, and Chandra P Sharma
February 2022, Polymers,
A C Jayalekshmi, and Sunita Prem Victor, and Chandra P Sharma
January 2016, International journal of nanomedicine,
A C Jayalekshmi, and Sunita Prem Victor, and Chandra P Sharma
April 2016, Materials (Basel, Switzerland),
A C Jayalekshmi, and Sunita Prem Victor, and Chandra P Sharma
July 2017, Materials science & engineering. C, Materials for biological applications,
A C Jayalekshmi, and Sunita Prem Victor, and Chandra P Sharma
July 2009, Tissue engineering. Part A,
A C Jayalekshmi, and Sunita Prem Victor, and Chandra P Sharma
May 2018, Journal of materials science. Materials in medicine,
A C Jayalekshmi, and Sunita Prem Victor, and Chandra P Sharma
May 2009, Acta biomaterialia,
A C Jayalekshmi, and Sunita Prem Victor, and Chandra P Sharma
June 2017, Journal of materials chemistry. B,
A C Jayalekshmi, and Sunita Prem Victor, and Chandra P Sharma
July 2017, Materials science & engineering. C, Materials for biological applications,
Copied contents to your clipboard!