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Investigation of oxidative metabolism in neutrophils (PMNs) from newborns was performed by measuring generation of superoxide anion (.O2-) and production of hydroxyl radical (.OH) in the resting state and after stimulation with opsonized zymosan or phorbol myristate acetate (PMA). Neutrophils from cord blood of ten term infants and normal adult controls were tested simultaneously. Cord PMNs generated significantly more .O2- than paired adult controls when stimulated with opsonized zymosan (P less than .01) and produced less .OH with PMA (P less than .005). When the amount of .O2- and .OH released by newborn PMNs with both stimuli was expressed as percent of values obtained from paired adult controls, there was a discrepancy in the generation of these two radicals: newborn PMNs produced relatively less .OH compared to .O2-. This decreased ability to produce .OH could underlie defective bactericidal activity in PMNs of neonates.
D R Ambruso, and
K M Altenburger, and
R B Johnston
December 1983,
The Journal of laboratory and clinical medicine,
D R Ambruso, and
K M Altenburger, and
R B Johnston
January 1990,
Medicina (Florence, Italy),
D R Ambruso, and
K M Altenburger, and
R B Johnston
December 1993,
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
D R Ambruso, and
K M Altenburger, and
R B Johnston
December 1986,
Toxicology and applied pharmacology,
D R Ambruso, and
K M Altenburger, and
R B Johnston
April 1988,
Thrombosis and haemostasis,
D R Ambruso, and
K M Altenburger, and
R B Johnston
November 1997,
Veterinary immunology and immunopathology,
D R Ambruso, and
K M Altenburger, and
R B Johnston
October 2007,
Free radical research,
D R Ambruso, and
K M Altenburger, and
R B Johnston
January 1989,
Free radical biology & medicine,
D R Ambruso, and
K M Altenburger, and
R B Johnston
March 2000,
Thrombosis and haemostasis,
D R Ambruso, and
K M Altenburger, and
R B Johnston
June 1986,
Biochemical and biophysical research communications,
