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The present work was done to investigate the possible effects of 3,4-oxo-isopropylidene-shikimic acid (ISA) on acetic acid (AA)-induced colitis in rats. Colitis was induced by intracolonic injection of 6 % AA. Several parameters, including macroscopic score and biochemical parameters, were determined to assess the degree of protection. Biochemical parameters such as myeloperoxidase (MPO) activity, malondialdehyde (MDA) and nitric oxide (NO) levels, and superoxide dismutase (SOD) and inducible NO synthase (NOS) activities were measured following standard assay procedures. The study showed that treatment of rats for 6 days with ISA (100 and 200 mg/kg) was able to give complete protection against AA-induced colitis. Moreover, biochemical changes were reversed and brought toward control. These results suggest a beneficial effect of ISA against experimental colitis and the possible mechanism of the protective effects may be partly due to an antioxidant action.
Jianfeng Xing, and
Jinyao Sun, and
Haisheng You, and
Jun Lv, and
Jianning Sun, and
Yalin Dong
April 2002,
Yao xue xue bao = Acta pharmaceutica Sinica,
Jianfeng Xing, and
Jinyao Sun, and
Haisheng You, and
Jun Lv, and
Jianning Sun, and
Yalin Dong
January 2017,
American journal of translational research,
Jianfeng Xing, and
Jinyao Sun, and
Haisheng You, and
Jun Lv, and
Jianning Sun, and
Yalin Dong
December 2003,
Yao xue xue bao = Acta pharmaceutica Sinica,
Jianfeng Xing, and
Jinyao Sun, and
Haisheng You, and
Jun Lv, and
Jianning Sun, and
Yalin Dong
February 2022,
Research in pharmaceutical sciences,
Jianfeng Xing, and
Jinyao Sun, and
Haisheng You, and
Jun Lv, and
Jianning Sun, and
Yalin Dong
February 2004,
Acta pharmacologica Sinica,
Jianfeng Xing, and
Jinyao Sun, and
Haisheng You, and
Jun Lv, and
Jianning Sun, and
Yalin Dong
February 2024,
Inflammation,
Jianfeng Xing, and
Jinyao Sun, and
Haisheng You, and
Jun Lv, and
Jianning Sun, and
Yalin Dong
January 2014,
Advanced biomedical research,
Jianfeng Xing, and
Jinyao Sun, and
Haisheng You, and
Jun Lv, and
Jianning Sun, and
Yalin Dong
March 2014,
Avicenna journal of phytomedicine,
Jianfeng Xing, and
Jinyao Sun, and
Haisheng You, and
Jun Lv, and
Jianning Sun, and
Yalin Dong
December 2002,
Vascular pharmacology,
Jianfeng Xing, and
Jinyao Sun, and
Haisheng You, and
Jun Lv, and
Jianning Sun, and
Yalin Dong
January 1999,
Pharmacological research,
