Biomaterial Database

[Experiences with labor induction at term with a PGE2 gel (Prepidil Gel) in unripe cervix]. 1990

V Bredow, and W Straube, and G Göretzlehner

Klinik für Gynäkologie und Geburtshilfe, Ernst-Moritz-Arndt-Universität Greifswald.

The induction of labour was started with an intracervical administration of 0.5 mg PGE2-Gel (Prepidil) in 30 gravidae at or near term with an unripe score of the cervix and for a medical indication. After excluding patients, where labour had already started subsequent to this measure, induction of labour was continued randomised with PGE2-gel intravaginal versus intravenous oxytocin. The progress of labour, the neonatal condition, and paraclinic values were examined. In 11 cases, labour had already started after the intracervical administration of PGE2. The Bishop-score of the other gravidae was improved in the mean from 2.5 +/- 1.1 to 5.5 +/- 1.7. Was the induction carried out with PGE2 vaginal, the rate of success rose to 5 of 9, and after infusion of oxytocin in 6 of 10 cases. The continued PGE2 vaginal inductions were insignificantly slower (p greater than 5%) than the inductions continued which oxytocin. The mean duration of labour was 7.7 +/- 3.4 hours in the PGE2-group and 4.5 +/- 2.6 hours in the oxytocin group. No disadvantages resulted for mother and child from the vaginal administration of PGE2. Because of the high rate of acceptance, vaginal administration of PGE2 is a suitable method for the safe induction of labour.

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007262	Infusions, Intravenous	The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.	Drip Infusions,Intravenous Drip,Intravenous Infusions,Drip Infusion,Drip, Intravenous,Infusion, Drip,Infusion, Intravenous,Infusions, Drip,Intravenous Infusion
D007751	Labor, Induced	Artificially induced UTERINE CONTRACTION.	Induced Labor,Induction of Labor,Labor Induced,Labor Induction,Induced, Labor,Induction, Labor,Inductions, Labor,Labor Inductions
D010121	Oxytocin	A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.	Ocytocin,Pitocin,Syntocinon
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D002584	Cervix Uteri	The neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal.	Cervical Canal of the Uterus,Cervical Canal, Uterine,Ectocervix,Endocervical Canal,Endocervix,External Os Cervix,External Os of the Cervix,Uterine Cervical Canal,Cervix,Cervixes,Uterine Cervix,Canal, Endocervical,Canal, Uterine Cervical,Cervix, External Os,Cervix, Uterine,Endocervical Canals,Uterine Cervical Canals
D005260	Female		Females
D005782	Gels	Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000282	Administration, Intravaginal	The insertion of drugs into the vagina to treat local infections, neoplasms, or to induce labor. The dosage forms may include medicated pessaries, irrigation fluids, and suppositories.	Administration, Vaginal,Drug Administration, Vaginal,Instillation, Vaginal,Intravaginal Administration,Vaginal Drug Administration,Vaginal Administration,Administration, Vaginal Drug,Administrations, Intravaginal,Administrations, Vaginal,Administrations, Vaginal Drug,Drug Administrations, Vaginal,Instillations, Vaginal,Intravaginal Administrations,Vaginal Administrations,Vaginal Drug Administrations,Vaginal Instillation,Vaginal Instillations