Biomaterial Database

Dose response to recombinant bovine somatotropin from weeks 15 to 44 postpartum in lactating dairy cows. 1990

R A Erdman, and B K Sharma, and R D Shaver, and R M Cleale

Animal Science Department, University of Maryland, College Park 20742.

Forty Holstein cows were used in an experiment to determine the response of cows to daily subcutaneous injections of 0, 10.3, 20.6, and 30.9 mg of recombinant bST. Injections began between 98 and 104 d postpartum and continued for 29 wk, up to 70 d prepartum, or a maximum of 400 d postpartum. Increasing recombinant bST increased milk yield and 3.5% FCM yield in a linear fashion and by 5.2 and 5.7 kg/d, respectively. Milk composition was not changed, and DM intake as a percentage of BW increased from 3.39 to 3.80% with increasing (30.9 mg/d) bST. Feed efficiency (3.5% FCM/DM intake) was increased from 1.35 to 1.64 with increasing dose, suggesting improved efficiency of use of DM intake, primarily by dilution of maintenance. Increasing bST reduced BW gain linearly from .46 kg/d for the control to .22 kg/d for the 30.9 mg/d bST. Calf birth weight, weight of cows at calving, and incidence of metabolic diseases during subsequent calving were not affected by bST. Somatotropin treatment resulted in somewhat smaller increased in milk yield than that reported in previous studies. Long-term health effects and effects on reproduction could not be determined from the relatively few cows used in this study.

UI	MeSH Term	Description	Entries
D007279	Injections, Subcutaneous	Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.	Subcutaneous Injections,Injection, Subcutaneous,Subcutaneous Injection
D007774	Lactation	The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.	Lactation, Prolonged,Milk Secretion,Lactations, Prolonged,Milk Secretions,Prolonged Lactation,Prolonged Lactations
D008892	Milk	The off-white liquid secreted by the mammary glands of humans and other mammals. It contains proteins, sugar, lipids, vitamins, and minerals.	Cow Milk,Cow's Milk,Milk, Cow,Milk, Cow's
D009752	Nutritional Status	State of the body in relation to the consumption and utilization of nutrients.	Nutrition Status,Status, Nutrition,Status, Nutritional
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011994	Recombinant Proteins	Proteins prepared by recombinant DNA technology.	Biosynthetic Protein,Biosynthetic Proteins,DNA Recombinant Proteins,Recombinant Protein,Proteins, Biosynthetic,Proteins, Recombinant DNA,DNA Proteins, Recombinant,Protein, Biosynthetic,Protein, Recombinant,Proteins, DNA Recombinant,Proteins, Recombinant,Recombinant DNA Proteins,Recombinant Proteins, DNA
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D002417	Cattle	Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.	Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260	Female		Females