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Forty-one elderly patients with mild to moderate hypertension (resting diastolic blood pressure 100-130 mmHg after an eight week placebo run-in phase) were randomised to a double-blind parallel group comparison of nifedipine retard 10 mg twice daily or atenolol 50 mg once daily. If the resting diastolic pressure exceeded 95 mmHg after four weeks of treatment the dose(s) were doubled for a further four weeks. Initial sitting blood pressures were 187 +/- 21/105 +/- 5 mmHg in the nifedipine group and 181 +/- 19/106 +/- 6 in the atenolol group. At four weeks, eight patients given nifedipine and nine given atenolol had their doses doubled. At eight weeks sitting blood pressures were 159 +/- 19/85 +/- 7 and 162 +/- 21/87 +/- 8 respectively, with 18/20 patients given nifedipine and 16/21 given atenolol having a sitting diastolic pressure equal to or less than 95 mmHg. One patient given nifedipine was withdrawn because of unacceptable ankle oedema and one given atenolol withdrawn because of worsening angina. Both drugs were equally acceptable to the patients and neither caused a change in their sense of well-being.
M Clamp, and
B Holmes, and
R Wilcox
January 1994,
Journal of human hypertension,
M Clamp, and
B Holmes, and
R Wilcox
January 1998,
Bollettino chimico farmaceutico,
M Clamp, and
B Holmes, and
R Wilcox
January 2001,
West African journal of medicine,
M Clamp, and
B Holmes, and
R Wilcox
January 1993,
The British journal of clinical practice,
M Clamp, and
B Holmes, and
R Wilcox
June 1989,
Cardiovascular drugs and therapy,
M Clamp, and
B Holmes, and
R Wilcox
July 1992,
The New Zealand medical journal,
M Clamp, and
B Holmes, and
R Wilcox
February 1989,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
M Clamp, and
B Holmes, and
R Wilcox
February 1986,
Ugeskrift for laeger,
M Clamp, and
B Holmes, and
R Wilcox
March 1994,
Arquivos brasileiros de cardiologia,
M Clamp, and
B Holmes, and
R Wilcox
December 1988,
American heart journal,
