BIOMAT Database Logo BIOMAT Database Logo

Dimethoate induced oxidative damage and histopathological changes in lung of adult rats: modulatory effects of selenium and/or vitamin E. 2012

Ibtissem Ben Amara, and Nejla Soudani, and Afef Troudi, and Ahmed Hakim, and Khaled Mounir Zeghal, and Tahia Boudawara, and Najiba Zeghal
Animal Physiology Laboratory, Faculty of Science, BP1171, 3000 Sfax, University of Sfax, Tunisia.

OBJECTIVE To determine the efficiency of selenium and/or vitamin E to alleviate lung oxidative damage induced by dimethoate, an organophosphorus compound. METHODS Adult Wistar rats were exposed during 30 days either to dimethoate (0.2 g/L of drinking water), dimethoate+selenium (0.5 mg/kg of diet), dimethoate+vitamin E (100 mg/kg of diet), or dimethoate+selenium+vitamin E. RESULTS Exposure to dimethoate caused oxidative stress in lung evidenced by an increase of malondialdehyde, protein carbonyl groups and advanced oxidation protein products. An increase in glutathione peroxidase, superoxide dismutase, catalase and a decrease in acetylcholinesterase and butyrylcholinesterase activities, glutathione, non-protein thiols and vitamins C levels were observed. Histopathological changes in lung tissue were noted as emphysema, hemorrhages and hemosiderin deposits. Co-administration of selenium or vitamin E to the diet of dimethoate treated rats ameliorated the biochemical parameters as well as histological impairments. The joint effect of these elements was more powerful in antagonizing dimethoate-induced lung oxidative damage. CONCLUSIONS We concluded that selenium and vitamin E ameliorated the toxic effects of this pesticide in lung tissue suggesting their role as potential antioxidants.

UI MeSH Term Description Entries
D008171 Lung Diseases Pathological processes involving any part of the LUNG. Pulmonary Diseases,Disease, Pulmonary,Diseases, Pulmonary,Pulmonary Disease,Disease, Lung,Diseases, Lung,Lung Disease
D002091 Butyrylcholinesterase An aspect of cholinesterase (EC 3.1.1.8). Pseudocholinesterase,Benzoylcholinesterase,Butyrylthiocholinesterase
D004117 Dimethoate An organothiophosphorus cholinesterase inhibitor that is used as a systemic and contact insecticide. Phosphamide,Bi-58,Rogor,Bi 58,Bi58
D005978 Glutathione A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. Reduced Glutathione,gamma-L-Glu-L-Cys-Gly,gamma-L-Glutamyl-L-Cysteinylglycine,Glutathione, Reduced,gamma L Glu L Cys Gly,gamma L Glutamyl L Cysteinylglycine
D000110 Acetylcholinesterase An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7. Acetylcholine Hydrolase,Acetylthiocholinesterase,Hydrolase, Acetylcholine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000975 Antioxidants Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. Anti-Oxidant,Antioxidant,Antioxidant Activity,Endogenous Antioxidant,Endogenous Antioxidants,Anti-Oxidant Effect,Anti-Oxidant Effects,Anti-Oxidants,Antioxidant Effect,Antioxidant Effects,Activity, Antioxidant,Anti Oxidant,Anti Oxidant Effect,Anti Oxidant Effects,Anti Oxidants,Antioxidant, Endogenous,Antioxidants, Endogenous
D001205 Ascorbic Acid A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. Vitamin C,Ascorbic Acid, Monosodium Salt,Ferrous Ascorbate,Hybrin,L-Ascorbic Acid,Magnesium Ascorbate,Magnesium Ascorbicum,Magnesium di-L-Ascorbate,Magnorbin,Sodium Ascorbate,Acid, Ascorbic,Acid, L-Ascorbic,Ascorbate, Ferrous,Ascorbate, Magnesium,Ascorbate, Sodium,L Ascorbic Acid,Magnesium di L Ascorbate,di-L-Ascorbate, Magnesium
D012643 Selenium An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE. Selenium-80,Selenium 80
D014810 Vitamin E A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.

Related Publications

Ibtissem Ben Amara, and Nejla Soudani, and Afef Troudi, and Ahmed Hakim, and Khaled Mounir Zeghal, and Tahia Boudawara, and Najiba Zeghal
Modulatory Role of Selenium and Vitamin E, Natural Antioxidants, against Bisphenol A-Induced Oxidative Stress in Wistar Albinos Rats.
July 2018, Toxicological research,
Ibtissem Ben Amara, and Nejla Soudani, and Afef Troudi, and Ahmed Hakim, and Khaled Mounir Zeghal, and Tahia Boudawara, and Najiba Zeghal
Protective effects of curcumin and vitamin E against chlorpyrifos-induced lung oxidative damage.
June 2015, Human & experimental toxicology,
Ibtissem Ben Amara, and Nejla Soudani, and Afef Troudi, and Ahmed Hakim, and Khaled Mounir Zeghal, and Tahia Boudawara, and Najiba Zeghal
Effects of vitamin E on cigarette smoke induced oxidative damage in larynx and lung.
January 2006, The Laryngoscope,
Ibtissem Ben Amara, and Nejla Soudani, and Afef Troudi, and Ahmed Hakim, and Khaled Mounir Zeghal, and Tahia Boudawara, and Najiba Zeghal
Dimethoate-induced biochemical and histopathological changes in the liver of rats.
November 2007, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie,
Ibtissem Ben Amara, and Nejla Soudani, and Afef Troudi, and Ahmed Hakim, and Khaled Mounir Zeghal, and Tahia Boudawara, and Najiba Zeghal
Selenium-vitamin E combination and melatonin modulates diabetes-induced blood oxidative damage and fetal outcomes in pregnant rats.
November 2011, Biological trace element research,
Ibtissem Ben Amara, and Nejla Soudani, and Afef Troudi, and Ahmed Hakim, and Khaled Mounir Zeghal, and Tahia Boudawara, and Najiba Zeghal
Effects of selenium with vitamin E and melatonin on cadmium-induced oxidative damage in rat liver and kidneys.
December 2008, Biological trace element research,
Ibtissem Ben Amara, and Nejla Soudani, and Afef Troudi, and Ahmed Hakim, and Khaled Mounir Zeghal, and Tahia Boudawara, and Najiba Zeghal
Monosodium glutamate-induced oxidative damage and genotoxicity in the rat: modulatory role of vitamin C, vitamin E and quercetin.
May 2006, Human & experimental toxicology,
Ibtissem Ben Amara, and Nejla Soudani, and Afef Troudi, and Ahmed Hakim, and Khaled Mounir Zeghal, and Tahia Boudawara, and Najiba Zeghal
Protective Effects of Selenium, Vitamin E, and Purple Carrot Anthocyanins on D-Galactose-Induced Oxidative Damage in Blood, Liver, Heart and Kidney Rats.
October 2016, Biological trace element research,
Ibtissem Ben Amara, and Nejla Soudani, and Afef Troudi, and Ahmed Hakim, and Khaled Mounir Zeghal, and Tahia Boudawara, and Najiba Zeghal
Protective effects of vitamin C and selenium supplementation on methomyl-induced tissue oxidative stress in adult rats.
January 2015, Toxicology and industrial health,
Ibtissem Ben Amara, and Nejla Soudani, and Afef Troudi, and Ahmed Hakim, and Khaled Mounir Zeghal, and Tahia Boudawara, and Najiba Zeghal
Selenium Alleviates Oxidative Stress and Lung Damage Induced by Aluminum Chloride in Adult Rats: Biochemical and Histological Approach.
March 2017, Biological trace element research,
Copied contents to your clipboard!