Biomaterial Database

Nuclear morphometry in grading transitional cell bladder cancer compared with subjective histological grading. 1990

P Lipponen, and M Eskelinen

Department of Pathology, University of Kuopio, Finland.

A retrospective study was performed comprising 265 bladder cancer patients. The patients were clinically followed up for an average of 10 years. The initial tumour biopsies were subjected to morphometric analysis. The mean nuclear area (NA), the standard deviation of nuclear area (SDNA) and the mean area of the 10 largest nuclei (NA10) were measured using IBAS 1&2 image analyzer. The prognostic value of NA, SDNA, NA10, papillary, subjective histological grading (WHO) and clinical stage (UICC) was evaluated. The progress in T-category was related to histological grade (p less than 0.0001), non-papillar growth (p = 0.0023), SDNA (p = 0.0110) and NA10 (p = 0.0305), in that order. The same parameters in addition to NA predicted lymph node involvement and metastasis. Recurrence rate was significantly related to NA10 (p = 0.0250). Non-papillar growth (p = 0.002), clinical stage (p = 0.005), histological grade (p = 0.0120), NA (p = 0.0143), SDNA (0.0383) and NA10 (p = 0.0632) predicted recurrence-free period. Bladder cancer survival was related to clinical stage (p less than 0.0001), histological grade (p less than 0.0001), SDNA (p less than 0.0001), non-papillar growth (p less than 0.0001), NA (p = 0.0001) and NA 10 (p = 0.0001), in that order. Grade II tumours could be regrouped prognostically using NA (p = 0.006), SDNA (p = 0.033) and NA10 (p = 0.016) as classifiers. Clinical stage, NA and histological grade predicted bladder cancer survival in a multiparameter analysis. The results show that NA and SDNA are powerful prognosticators of survival. NA10 and SDNA predict progression better than NA. The multiparameter analysis identified clinical stage, histological grade and NA as the most important prognosticators of survival.

UI	MeSH Term	Description	Entries
D009367	Neoplasm Staging	Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.	Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D011379	Prognosis	A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.	Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D001749	Urinary Bladder Neoplasms	Tumors or cancer of the URINARY BLADDER.	Bladder Cancer,Bladder Neoplasms,Cancer of Bladder,Bladder Tumors,Cancer of the Bladder,Malignant Tumor of Urinary Bladder,Neoplasms, Bladder,Urinary Bladder Cancer,Bladder Cancers,Bladder Neoplasm,Bladder Tumor,Cancer, Bladder,Cancer, Urinary Bladder,Neoplasm, Bladder,Neoplasm, Urinary Bladder,Tumor, Bladder,Tumors, Bladder,Urinary Bladder Neoplasm
D002295	Carcinoma, Transitional Cell	A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.	Carcinomas, Transitional Cell,Cell Carcinoma, Transitional,Cell Carcinomas, Transitional,Transitional Cell Carcinoma,Transitional Cell Carcinomas
D002467	Cell Nucleus	Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	Cell Nuclei,Nuclei, Cell,Nucleus, Cell
D005500	Follow-Up Studies	Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.	Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000704	Analysis of Variance	A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.	ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D001706	Biopsy	Removal and pathologic examination of specimens from the living body.	Biopsies