Diazepam effects on the exploratory behaviour of rats in an elevated runway: evidence for biphasic effects of benzodiazepines. 1990

S L Widgiz, and C H Beck
Department of Psychology, University of Alberta, Edmonton, Canada.

The purpose of this study was to test the validity of the fear-reduction model of benzodiazepine (BZ) action on the exploration of novelty. According to this hypothesis an animal given a tranquilizer should selectively increase the amount of investigative behaviour in the more novel portion of an elevated maze. To permit comparison of the same behaviours at both ends of the maze, an elevated runway was built with a wall running lengthwise along the midline of one end. In the first experiment, male Sprague-Dawley rats treated with diazepam (2.0 mg/kg, i.p., -30 min) compared to saline-treated animals, increased the time spent exploring the open end of the runway but not the wall end of the runway, thus supporting the fear-reduction model. However, saline-treated animals, made less fearful by repeated prior exposure to the runway, did not show a similar increase in open-end exploration. Instead, they habituated to the novelty of the runway, as grooming and sitting still replaced investigation. In Experiment 2, exploration was rewarded by adding to the open end of the runway a patch of litter soiled by a female rat. This produced a behavioural pattern in naive saline-treated rats very similar to that seen in naive diazepam-treated rats in the first experiment. In Experiment 3, diazepam potentiated the habituation of rats previously familiarized with the runway. The initial increase and subsequent decrease in exploration caused by diazepam were encompassed by the biphasic model of BZ action more adequately than either the fear-reduction or reward-enhancement models.

UI MeSH Term Description Entries
D008297 Male Males
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D003975 Diazepam A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity. 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one,Apaurin,Diazemuls,Faustan,Relanium,Seduxen,Sibazon,Stesolid,Valium
D005106 Exploratory Behavior The tendency to explore or investigate a novel environment. It is considered a motivation not clearly distinguishable from curiosity. Curiosity,Novelty-Seeking Behavior,Behavior, Exploratory,Behavior, Novelty-Seeking,Behaviors, Exploratory,Behaviors, Novelty-Seeking,Curiosities,Exploratory Behaviors,Novelty Seeking Behavior,Novelty-Seeking Behaviors
D005239 Fear The affective response to an actual current external danger which subsides with the elimination of the threatening condition. Threat Cues,Threat Sensitivity,Cue, Threat,Fears,Sensitivity, Threat,Threat Cue,Threat Sensitivities
D006185 Habituation, Psychophysiologic The disappearance of responsiveness to a repeated stimulation. It does not include drug habituation. Habituation (Psychophysiology),Habituation, Psychophysiological,Psychophysiologic Habituation,Psychophysiological Habituation,Habituations (Psychophysiology)
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001143 Arousal Cortical vigilance or readiness of tone, presumed to be in response to sensory stimulation via the reticular activating system. Vigilance, Cortical,Arousals,Cortical Vigilance
D012931 Social Environment The aggregate of social and cultural institutions, forms, patterns, and processes that influence the life of an individual or community. Social Context,Environment, Social,Social Ecology,Context, Social,Contexts, Social,Ecologies, Social,Ecology, Social,Environments, Social,Social Contexts,Social Ecologies,Social Environments

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