Biomaterial Database

[Animal experiment model of the effect of ultraviolet irradiation on hexachlorobenzene-induced porphyria]. 1990

P Lehmann, and T Schäfer, and K Bolsen, and G Goerz

Hautklinik Heinrich-Heine-Universität Düsseldorf.

The Effect of UV-Irradiation on the Hexachlorobenzene-induced Porphyria in an Experimental Animal Model Hexachlorobenzene is able to induce in humans and different animal species a hepatic porphyria, which is comparable to porphyria cutanea tarda. We studied whether hexachlorobenzene feeding could induce this porphyria also in hairless rats (Rowett-Nude), as these are suitable for photobiologic studies. After development of hepatic porphyria the rats were irradiated either with UV-A or UV-B light. Biochemical effects on the porphyrin metabolism and clinical as well as histologic skin changes were examined. In the liver of the porphyric rats, UV-A and UV-B irradiation induced increased aminolevulinic acid synthase activity accompanied with augmentation of hepatic porphyrin content. UV-A or UV-B irradiation also lead to increased total porphyrin contents in the skin of porphyric compared to non-irradiated animals. Clinically and histologically, however, only UV-A irradiation induced lesions, which were comparable to skin manifestations of porphyria cutanea tarda.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008107	Liver Diseases	Pathological processes of the LIVER.	Liver Dysfunction,Disease, Liver,Diseases, Liver,Dysfunction, Liver,Dysfunctions, Liver,Liver Disease,Liver Dysfunctions
D011164	Porphyrias	A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.	Porphyria,Porphyrin Disorder,Disorder, Porphyrin,Disorders, Porphyrin,Porphyrin Disorders
D011166	Porphyrins	A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.	Porphyrin
D011923	Rats, Nude	A mutant strain of Rattus norvegicus without a thymus and with depressed or absent T-cell function. This strain of rats may have a small amount of hair at times, but then lose it.	Athymic Rats,Nude Rats,Rats, Athymic,Athymic Rat,Nude Rat,Rat, Athymic,Rat, Nude
D004307	Dose-Response Relationship, Radiation	The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.	Dose Response Relationship, Radiation,Dose-Response Relationships, Radiation,Radiation Dose-Response Relationship,Radiation Dose-Response Relationships,Relationship, Radiation Dose-Response,Relationships, Radiation Dose-Response
D005260	Female		Females
D006581	Hexachlorobenzene	An agricultural fungicide and seed treatment agent.	HCB
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012871	Skin Diseases	Diseases involving the DERMIS or EPIDERMIS.	Dermatoses,Skin and Subcutaneous Tissue Disorders,Dermatosis,Skin Disease