BIOMAT Database Logo BIOMAT Database Logo

HLA-DQ association and allele competition in Chinese narcolepsy. 2012

F Han, and L Lin, and J Li, and S X Dong, and P An, and L Zhao, and N Y Liu, and Q Y Li, and H Yan, and Z C Gao, and J Faraco, and K P Strohl, and X Liu, and H Miyadera, and E Mignot
Department of Pulmonary Medicine, Beijing University People's Hospital, Beijing, China. hanfang1@hotmail.com

In Japanese, Koreans and Caucasians, narcolepsy/hypocretin deficiency is tightly associated with the DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype. Studies in African-Americans suggest a primary effect of DQB1*06:02, but this observation has been difficult to confirm in other populations because of high linkage disequilibrium between DRB1*15:01/3 and DQB1*06:02 in most populations. In this study, we studied human leucocyte antigen (HLA) class II in 202 Chinese narcolepsy patients (11% from South China) and found all patients to be DQB1*06:02 positive. Comparing cases with 103 unselected controls, and 110 and 79 controls selected for the presence of DQB1*06:02 and DRB1*15:01, we found that the presence of DQB1*06:02 and not DRB1*15:01 was associated with narcolepsy. In particular, Southern Chinese haplotypes such as the DRB1*15:01-DQA1*01:02-DQB1*06:01 and DRB1*15:01-DQA1*01:02-DQB1*05 were not associated with narcolepsy. As reported in Japanese, Koreans, African-Americans and Caucasians, additional protective effects of DQA1*01 (non-DQA1*01:02) and susceptibility effects of DQB1*03:01 were observed. These results illustrate the extraordinary conservation of HLA class II effects in narcolepsy across populations and show that DRB1*15:01 has no effect on narcolepsy susceptibility in the absence of DQB1*06:02. The results are also in line with a previously proposed 'HLA-DQ allelic competition model' that involves competition between non-DQA1*01:02, non-DQB1*06:02 'competent' (able to dimerize together) DQ1 alleles and the major DQα*01:02/ DQβ*06:02 narcolepsy heterodimer to reduce susceptibility.

UI MeSH Term Description Entries
D008297 Male Males
D009290 Narcolepsy A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7) Gelineau Syndrome,Narcolepsy-Cataplexy Syndrome,Paroxysmal Sleep,Gelineau's Syndrome,Narcoleptic Syndrome,Gelineau's Syndromes,Gelineaus Syndrome,Narcolepsy Cataplexy Syndrome,Narcolepsy-Cataplexy Syndromes,Narcoleptic Syndromes,Sleep, Paroxysmal,Syndrome, Gelineau,Syndrome, Gelineau's,Syndrome, Narcolepsy-Cataplexy,Syndrome, Narcoleptic,Syndromes, Gelineau's,Syndromes, Narcolepsy-Cataplexy,Syndromes, Narcoleptic
D009479 Neuropeptides Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells. Neuropeptide
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005260 Female Females
D005787 Gene Frequency The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION. Allele Frequency,Genetic Equilibrium,Equilibrium, Genetic,Allele Frequencies,Frequencies, Allele,Frequencies, Gene,Frequency, Allele,Frequency, Gene,Gene Frequencies
D006239 Haplotypes The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX. Haplotype
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000068797 Orexins Neuropeptide hormones that play a role in regulating a variety of behavioral and physiological processes in response to motivational stimuli. Hypocretin,Orexin,Hypocretin-1,Hypocretin-2,Hypocretins,Orexin-A,Orexin-B,Hypocretin 1,Hypocretin 2,Orexin A,Orexin B

Related Publications

F Han, and L Lin, and J Li, and S X Dong, and P An, and L Zhao, and N Y Liu, and Q Y Li, and H Yan, and Z C Gao, and J Faraco, and K P Strohl, and X Liu, and H Miyadera, and E Mignot
HLA-DQ allele competition in narcolepsy: where is the evidence?
January 2015, Sleep,
F Han, and L Lin, and J Li, and S X Dong, and P An, and L Zhao, and N Y Liu, and Q Y Li, and H Yan, and Z C Gao, and J Faraco, and K P Strohl, and X Liu, and H Miyadera, and E Mignot
[HLA-DRB and -DQB allele contribution to narcolepsy susceptibility in Chinese patients with narcolepsy].
April 2003, Zhonghua yi xue za zhi,
F Han, and L Lin, and J Li, and S X Dong, and P An, and L Zhao, and N Y Liu, and Q Y Li, and H Yan, and Z C Gao, and J Faraco, and K P Strohl, and X Liu, and H Miyadera, and E Mignot
Association of an HLA-DQ allele with clinical tuberculosis.
January 1998, JAMA,
F Han, and L Lin, and J Li, and S X Dong, and P An, and L Zhao, and N Y Liu, and Q Y Li, and H Yan, and Z C Gao, and J Faraco, and K P Strohl, and X Liu, and H Miyadera, and E Mignot
HLA-DQ allele competition in narcolepsy: a comment on Tafti et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe.
January 2015, Sleep,
F Han, and L Lin, and J Li, and S X Dong, and P An, and L Zhao, and N Y Liu, and Q Y Li, and H Yan, and Z C Gao, and J Faraco, and K P Strohl, and X Liu, and H Miyadera, and E Mignot
Association Study of HLA-DQB1*0602 Allele in Iranian Patients with Narcolepsy.
October 2017, Iranian journal of allergy, asthma, and immunology,
F Han, and L Lin, and J Li, and S X Dong, and P An, and L Zhao, and N Y Liu, and Q Y Li, and H Yan, and Z C Gao, and J Faraco, and K P Strohl, and X Liu, and H Miyadera, and E Mignot
HLA-DQ alpha genotype and allele frequencies in Malays, Chinese, and Indians in the Malaysian population.
January 1994, Human heredity,
F Han, and L Lin, and J Li, and S X Dong, and P An, and L Zhao, and N Y Liu, and Q Y Li, and H Yan, and Z C Gao, and J Faraco, and K P Strohl, and X Liu, and H Miyadera, and E Mignot
Association analysis of the major histocompatibility complex, class II, DQ β1 gene, HLA-DQB1, with narcolepsy in Han Chinese patients from Taiwan.
December 2013, Sleep medicine,
F Han, and L Lin, and J Li, and S X Dong, and P An, and L Zhao, and N Y Liu, and Q Y Li, and H Yan, and Z C Gao, and J Faraco, and K P Strohl, and X Liu, and H Miyadera, and E Mignot
HLA DQ alpha genotype and allele frequencies in Qatari population.
November 1997, Forensic science international,
F Han, and L Lin, and J Li, and S X Dong, and P An, and L Zhao, and N Y Liu, and Q Y Li, and H Yan, and Z C Gao, and J Faraco, and K P Strohl, and X Liu, and H Miyadera, and E Mignot
HLA-DQ, DR allele polymorphism of type 1 diabetes in the Chinese population: a meta-analysis.
April 2009, Chinese medical journal,
F Han, and L Lin, and J Li, and S X Dong, and P An, and L Zhao, and N Y Liu, and Q Y Li, and H Yan, and Z C Gao, and J Faraco, and K P Strohl, and X Liu, and H Miyadera, and E Mignot
No association between HLA-DQ and -DR genotypes with nasopharyngeal carcinoma in southern Chinese.
May 1995, Cancer genetics and cytogenetics,
Copied contents to your clipboard!