-transparent.png){kind=logo}
8-Bromoadenine nucleotides were tested as potential substrates and/or inhibitors of mitochondrial processes in intact or disrupted organelles, as substrates of various phosphotransferases, and as allosteric effectors in the reactions catalyzed by phosphofructokinase, isocitrate dehydrogenase, glutamate dehydrogenase, and fructose-1,6-bisphosphatase. 8-BrATP and 8-BrADP are not recognized by the translocase system located in the inner mitochondrial membrane and cannot be used as usbstrates in oxidative phosphorylation and related reactions catalyzed be beef heart submitochondrial membranes. This confirms the high specificity for adenine nucleotides of the mammalian systems involved in energy-yielding and energy-requiring reactions. However, 8-BrATP and 8-BrADP are able to substitute for the natural adenine nucleotides in reactions catalyzed by many phosphotransferases, although their capacity as phosphate donors and acceptors is generally much reduced. On the other hand, in almost all investigated cases, the 8-bromoadenine nucleotides have lost the capability of the natural adenine nucleotides to act as allosteric effectors, indicating that the structural requirements for allosteric activity are more stringent than those for catalytic activity.
I Lascu, and
M Kezdi, and
I Goia, and
G Jebeleanu, and
O Bârzu, and
A Pansini, and
S Papa, and
H H Mantsch
August 1980,
Tsitologiia,
I Lascu, and
M Kezdi, and
I Goia, and
G Jebeleanu, and
O Bârzu, and
A Pansini, and
S Papa, and
H H Mantsch
December 1972,
The Journal of organic chemistry,
I Lascu, and
M Kezdi, and
I Goia, and
G Jebeleanu, and
O Bârzu, and
A Pansini, and
S Papa, and
H H Mantsch
December 1975,
Biochemistry,
I Lascu, and
M Kezdi, and
I Goia, and
G Jebeleanu, and
O Bârzu, and
A Pansini, and
S Papa, and
H H Mantsch
January 1997,
Applied biochemistry and biotechnology,
I Lascu, and
M Kezdi, and
I Goia, and
G Jebeleanu, and
O Bârzu, and
A Pansini, and
S Papa, and
H H Mantsch
January 1982,
Radiobiologiia,
I Lascu, and
M Kezdi, and
I Goia, and
G Jebeleanu, and
O Bârzu, and
A Pansini, and
S Papa, and
H H Mantsch
August 1971,
Biochimica et biophysica acta,
I Lascu, and
M Kezdi, and
I Goia, and
G Jebeleanu, and
O Bârzu, and
A Pansini, and
S Papa, and
H H Mantsch
July 1955,
The Journal of biological chemistry,
I Lascu, and
M Kezdi, and
I Goia, and
G Jebeleanu, and
O Bârzu, and
A Pansini, and
S Papa, and
H H Mantsch
January 2019,
Physical chemistry chemical physics : PCCP,
I Lascu, and
M Kezdi, and
I Goia, and
G Jebeleanu, and
O Bârzu, and
A Pansini, and
S Papa, and
H H Mantsch
February 2017,
Nanoscale,
I Lascu, and
M Kezdi, and
I Goia, and
G Jebeleanu, and
O Bârzu, and
A Pansini, and
S Papa, and
H H Mantsch
July 1969,
Journal of molecular biology,
