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1. Methyleugenol (MEG) has been used as a flavouring agent in food, as a fragrance in cosmetic products, and as an insect attractant. MEG was carcinogenic in both rats and mice following gavage administration. In this study we investigated plasma toxicokinetics of MEG in F344 rats and B6C3F₁ mice of both sexes following single gavage (37, 75, or 150 mg/kg) and intravenous (IV) (37 mg/kg) administration. 2. Following IV administration, MEG was rapidly distributed and cleared from the systemic circulation in both species and sexes. Absorption of MEG was rapid following gavage administration with secondary peaks in the plasma MEG concentration-versus-time profiles. C(max) and AUC(T) increased and the clearance decreased greater than proportional to the dose in rats and mice of both sexes. In general, rats had higher internal exposure to MEG than mice. 3. The results for AUC(T) and clearance suggest that perhaps the metabolism of MEG is saturated at higher doses tested in this study. Absolute bioavailability following gavage administration of 37 mg/kg was low in both rats (~4%) and mice (7-9%) of both sexes indicating extensive first-pass metabolism. There was no sex difference in plasma toxicokinetics of MEG following gavage administration both in rats and mice.
S Peter Hong, and
Alfred F Fuciarelli, and
Jerry D Johnson, and
Steven W Graves, and
Derrick J Bates, and
Suramya Waidyanatha, and
Cynthia S Smith
August 2000,
Journal of agricultural and food chemistry,
S Peter Hong, and
Alfred F Fuciarelli, and
Jerry D Johnson, and
Steven W Graves, and
Derrick J Bates, and
Suramya Waidyanatha, and
Cynthia S Smith
April 1993,
Xenobiotica; the fate of foreign compounds in biological systems,
S Peter Hong, and
Alfred F Fuciarelli, and
Jerry D Johnson, and
Steven W Graves, and
Derrick J Bates, and
Suramya Waidyanatha, and
Cynthia S Smith
December 1992,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
S Peter Hong, and
Alfred F Fuciarelli, and
Jerry D Johnson, and
Steven W Graves, and
Derrick J Bates, and
Suramya Waidyanatha, and
Cynthia S Smith
April 1996,
Toxicology,
S Peter Hong, and
Alfred F Fuciarelli, and
Jerry D Johnson, and
Steven W Graves, and
Derrick J Bates, and
Suramya Waidyanatha, and
Cynthia S Smith
April 2003,
Cancer letters,
S Peter Hong, and
Alfred F Fuciarelli, and
Jerry D Johnson, and
Steven W Graves, and
Derrick J Bates, and
Suramya Waidyanatha, and
Cynthia S Smith
January 2013,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
S Peter Hong, and
Alfred F Fuciarelli, and
Jerry D Johnson, and
Steven W Graves, and
Derrick J Bates, and
Suramya Waidyanatha, and
Cynthia S Smith
April 2001,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
S Peter Hong, and
Alfred F Fuciarelli, and
Jerry D Johnson, and
Steven W Graves, and
Derrick J Bates, and
Suramya Waidyanatha, and
Cynthia S Smith
July 1999,
Toxicology and applied pharmacology,
S Peter Hong, and
Alfred F Fuciarelli, and
Jerry D Johnson, and
Steven W Graves, and
Derrick J Bates, and
Suramya Waidyanatha, and
Cynthia S Smith
June 2002,
Journal of toxicology and environmental health. Part A,
S Peter Hong, and
Alfred F Fuciarelli, and
Jerry D Johnson, and
Steven W Graves, and
Derrick J Bates, and
Suramya Waidyanatha, and
Cynthia S Smith
June 2003,
Mycotoxin research,
