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A 34-year-old man presented with classic glucagonoma syndrome manifested by weight loss, dermatitis, stomatitis, anemia, and mild diabetes mellitus. The diagnosis of glucagonoma was made by light and electron microscopic demonstration of a metastatic alpha cell carcinoma in a liver biopsy specimen. Plasma glucagon concentration was abnormally high. The patient also had symptoms and signs of involvement of the central nervous system. Radionuclide and CAT scans of the brain, negative CSF cytology and myelography excluded the possibility of metastases or other space-occupying lesions. Glucagon was demonstrated in the CSF. We postulate that the neurologic symptoms were due to direct or indirect effect of this hormone on the brain. Following therapy with streptozotocin and 5-fluorouracil, the patient had a subjective and objective clinical and hormonal remission of his disease including amelioration of his neurological impairment.
J D Khandekar, and
D Oyer, and
H J Miller, and
N A Vick
September 1992,
The American journal of medicine,
J D Khandekar, and
D Oyer, and
H J Miller, and
N A Vick
September 1980,
Annals of internal medicine,
J D Khandekar, and
D Oyer, and
H J Miller, and
N A Vick
May 1979,
Cancer treatment reports,
J D Khandekar, and
D Oyer, and
H J Miller, and
N A Vick
November 1988,
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J D Khandekar, and
D Oyer, and
H J Miller, and
N A Vick
October 1977,
Cancer treatment reports,
J D Khandekar, and
D Oyer, and
H J Miller, and
N A Vick
January 2010,
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J D Khandekar, and
D Oyer, and
H J Miller, and
N A Vick
June 1982,
Clinical oncology,
J D Khandekar, and
D Oyer, and
H J Miller, and
N A Vick
February 1989,
American journal of clinical oncology,
J D Khandekar, and
D Oyer, and
H J Miller, and
N A Vick
September 2004,
Clinical cancer research : an official journal of the American Association for Cancer Research,
J D Khandekar, and
D Oyer, and
H J Miller, and
N A Vick
October 2001,
Cancer research and treatment,
