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A total of 58 patients with histologically confirmed chronic viral hepatitis B and presence of HBsAg and HBV-DNA in the serum were randomized in a prospectively controlled trial. 30 patients were treated with 3 megaunits of rIFN a-2b s.c. thrice weekly for 4 months. 28 controls received no treatment. The post-treatment follow-up period consisted of 6 months. 28 patients treated and 27 controls completed the protocol. One female patient of the treatment group showed a complete response (loss of HBsAg, HBeAg and HBV-DNA), 8 other patients (32%) revealed a partial response to therapy (loss of HBeAg and HBV-DNA). Three patients of the control-group (11%) lost HBeAg and HBV-DNA spontaneously. This finding is statistically significant (p less than 0.05). The elimination of HBV-markers from the serum was associated with a normalization of aminotransferase activities in the serum. A reactivation of hepatitis was not observed after seroconversion.
R Baumgarten, and
R Müller, and
R Markus, and
B Hintsche-Kilger, and
J D Fengler, and
H Meisel
July 2004,
Journal of gastroenterology and hepatology,
R Baumgarten, and
R Müller, and
R Markus, and
B Hintsche-Kilger, and
J D Fengler, and
H Meisel
October 1996,
Journal of tropical pediatrics,
R Baumgarten, and
R Müller, and
R Markus, and
B Hintsche-Kilger, and
J D Fengler, and
H Meisel
October 1992,
Journal of chemotherapy (Florence, Italy),
R Baumgarten, and
R Müller, and
R Markus, and
B Hintsche-Kilger, and
J D Fengler, and
H Meisel
May 1995,
Annals of internal medicine,
R Baumgarten, and
R Müller, and
R Markus, and
B Hintsche-Kilger, and
J D Fengler, and
H Meisel
October 1996,
American family physician,
R Baumgarten, and
R Müller, and
R Markus, and
B Hintsche-Kilger, and
J D Fengler, and
H Meisel
January 2005,
European journal of dermatology : EJD,
R Baumgarten, and
R Müller, and
R Markus, and
B Hintsche-Kilger, and
J D Fengler, and
H Meisel
January 1991,
Przeglad epidemiologiczny,
R Baumgarten, and
R Müller, and
R Markus, and
B Hintsche-Kilger, and
J D Fengler, and
H Meisel
March 2007,
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology,
R Baumgarten, and
R Müller, and
R Markus, and
B Hintsche-Kilger, and
J D Fengler, and
H Meisel
January 1992,
Infection,
R Baumgarten, and
R Müller, and
R Markus, and
B Hintsche-Kilger, and
J D Fengler, and
H Meisel
January 2003,
World journal of gastroenterology,
