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A comparative study of phospho- and glycosphingolipids of cultured skin fibroblast from healthy donors and from patients with systemic sclerodermia (SSD) was carried out. It was shown that the total phospholipid content in SSD fibroblasts is elevated. No significant changes in the concentration of neutral glycosphingolipids were observed. The ganglioside composition of SSD cell cultures differs significantly from that of healthy donor cells. The concentration of the gangliosides, GM3 and GM1, is decreased; no ganglioside GD1a was found in SSD fibroblasts. The data obtained are suggestive of changes in the properties of fibroblast surface which can be manifested both in the impaired reception of matrix proteins and in the impairment of basic properties of the membrane. These changes are well correlated with the results of previous studies on the AMP cyclase system.
N D Gabriélian, and
N V Prokazova, and
A V Komleva, and
L N Kashnikova, and
I V Efimova, and
A F Panasiuk
January 1995,
Clinical and experimental rheumatology,
N D Gabriélian, and
N V Prokazova, and
A V Komleva, and
L N Kashnikova, and
I V Efimova, and
A F Panasiuk
August 1984,
Annals of neurology,
N D Gabriélian, and
N V Prokazova, and
A V Komleva, and
L N Kashnikova, and
I V Efimova, and
A F Panasiuk
January 1984,
Voprosy meditsinskoi khimii,
N D Gabriélian, and
N V Prokazova, and
A V Komleva, and
L N Kashnikova, and
I V Efimova, and
A F Panasiuk
January 1988,
Dermatologica,
N D Gabriélian, and
N V Prokazova, and
A V Komleva, and
L N Kashnikova, and
I V Efimova, and
A F Panasiuk
September 1972,
The Journal of biological chemistry,
N D Gabriélian, and
N V Prokazova, and
A V Komleva, and
L N Kashnikova, and
I V Efimova, and
A F Panasiuk
September 1972,
The Journal of biological chemistry,
N D Gabriélian, and
N V Prokazova, and
A V Komleva, and
L N Kashnikova, and
I V Efimova, and
A F Panasiuk
December 1989,
Biulleten' eksperimental'noi biologii i meditsiny,
N D Gabriélian, and
N V Prokazova, and
A V Komleva, and
L N Kashnikova, and
I V Efimova, and
A F Panasiuk
January 2000,
Scandinavian journal of rheumatology,
N D Gabriélian, and
N V Prokazova, and
A V Komleva, and
L N Kashnikova, and
I V Efimova, and
A F Panasiuk
January 1982,
Voprosy meditsinskoi khimii,
N D Gabriélian, and
N V Prokazova, and
A V Komleva, and
L N Kashnikova, and
I V Efimova, and
A F Panasiuk
January 1984,
Terapevticheskii arkhiv,
