-transparent.png){kind=logo}
Applying recombinant DNA techniques, the structures of red pigment gene (RPG) and green pigment gene (GPG) were analyzed for 43 patients with protan or deutan (including 3 females), 4 normal relatives and 3 carriers out of 3 families, as well as 11 normal controls. Abnormality of RPG was detected in all 19 protan and that of GPG was found in 14 out of 24 deutan. In about 80% (32/40) of protan and deutan the changing of exon 5 for RPG or GPG was discovered. In protan the normal RPG was replaced by a 5' red -3' green hybrid gene. Some of the deutan had no GPG, some had 5' green -3' red hybrid gene with or without GPG. Furthermore, the exon 5 of RPG and GPG was amplified by polymerase chain reaction (PCR) and further analyzed by Rsa I digestion. The results for PCR are identical to that of Southern blot hybridization.
Q Zhang, and
W Mao, and
Q Ma, and
R Zeng, and
L Wu, and
D Z Wu, and
Y Chen
November 1996,
Science (New York, N.Y.),
Q Zhang, and
W Mao, and
Q Ma, and
R Zeng, and
L Wu, and
D Z Wu, and
Y Chen
February 1995,
Science (New York, N.Y.),
Q Zhang, and
W Mao, and
Q Ma, and
R Zeng, and
L Wu, and
D Z Wu, and
Y Chen
November 1998,
Vision research,
Q Zhang, and
W Mao, and
Q Ma, and
R Zeng, and
L Wu, and
D Z Wu, and
Y Chen
February 1980,
Science (New York, N.Y.),
Q Zhang, and
W Mao, and
Q Ma, and
R Zeng, and
L Wu, and
D Z Wu, and
Y Chen
September 1998,
Yan ke xue bao = Eye science,
Q Zhang, and
W Mao, and
Q Ma, and
R Zeng, and
L Wu, and
D Z Wu, and
Y Chen
January 2011,
Fly,
Q Zhang, and
W Mao, and
Q Ma, and
R Zeng, and
L Wu, and
D Z Wu, and
Y Chen
December 1964,
Scientific American,
Q Zhang, and
W Mao, and
Q Ma, and
R Zeng, and
L Wu, and
D Z Wu, and
Y Chen
January 2002,
Human molecular genetics,
Q Zhang, and
W Mao, and
Q Ma, and
R Zeng, and
L Wu, and
D Z Wu, and
Y Chen
January 1999,
Duodecim; laaketieteellinen aikakauskirja,
Q Zhang, and
W Mao, and
Q Ma, and
R Zeng, and
L Wu, and
D Z Wu, and
Y Chen
January 1971,
Transactions - American Academy of Ophthalmology and Otolaryngology. American Academy of Ophthalmology and Otolaryngology,
