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Stability of prednisolone and prednisolone acetate in various vehicles used in semi-solid topical preparations. 1990

P Christen, and F Kloeti, and B Gander
Department of Pharmacognosy, University of Geneva, Switzerland.

The stability of prednisolone and prednisolone acetate has been investigated at 37 degrees C in seven semi-solid vehicles, including almond oil, beeswax, Cremophor RH 40, Lanette N, and hydrogel formulations of hydroxy-propylcellulose, carbomer and bentonite. Extraction methods and a high-performance liquid chromatographic (HPLC) procedure have been developed in order to assay the content of undegraded steroid at time 0 and after 28 days. Prednisolone acetate showed superior stability compared to prednisolone. Bentonite induced considerable degradation of both steroid compounds, whereas the two absorption bases, Cremophor RH 40 and Lanette N, affected mainly the stability of prednisolone. In the carbomer hydrogel, prednisolone acetate hydrolysed to a small extent during the trituration process. The most effective steroid stability was found in the two lipophilic bases and the hydroxypropylcellulose hydrogel.

UI MeSH Term Description Entries
D011239 Prednisolone A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. Di-Adreson-F,Predate,Predonine,Di Adreson F,DiAdresonF
D002851 Chromatography, High Pressure Liquid Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed. Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D004355 Drug Stability The chemical and physical integrity of a pharmaceutical product. Drug Shelf Life,Drugs Shelf Lives,Shelf Life, Drugs,Drug Stabilities,Drugs Shelf Life,Drugs Shelf Live,Life, Drugs Shelf,Shelf Life, Drug,Shelf Live, Drugs,Shelf Lives, Drugs
D005782 Gels Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.
D000287 Administration, Topical The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example. Drug Administration, Topical,Administration, Topical Drug,Topical Administration,Topical Drug Administration,Administrations, Topical,Administrations, Topical Drug,Drug Administrations, Topical,Topical Administrations,Topical Drug Administrations
D014677 Pharmaceutical Vehicles A carrier or inert medium used as a solvent (or diluent) in which the medicinally active agent is formulated and or administered. (Dictionary of Pharmacy, 1986) Pharmaceutical Vehicle,Vehicle, Pharmaceutical,Vehicles, Pharmaceutical

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