Anticlastogenic effect of diosgenin on 7,12-dimethylbenz(a)anthracene treated experimental animals. 2013

K Rajalingam, and G Sugunadevi, and M A Vijayaanand, and J Sathiyapriya, and K Sivakumar, and K Suresh
Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar – 608 002, Tamilnadu, India.

The present investigation explores the anticlastogenic effect of diosgenin on 7,12-dimethylbenz(a)anthracene (DMBA) treated clastogenesis. The frequency of bone marrow micronucleated polychromatic erythrocytes (MnPCEs), chromosomal aberrations (CA), deoxyribonucleic acid (DNA) damage as cytogenetic markers and the levels of lipid peroxidation by-products, activities of enzymatic antioxidant and the status of detoxification agents were performed to assess the anticlastogenic effects of diosgenin on DMBA treated hamsters. Intraperitoneal injection of DMBA (30 mg/kg bw) leads to clastogenesis in hamster. Elevated MnPCEs frequencies, CA, DNA damage, enhanced lipid peroxidation by products, declined antioxidant activities and detoxification cascade were observed in DMBA treated hamsters. Oral pretreatment with diosgenin (80 mg/kg bw) daily for a period of five days significantly reduced the frequency of MnPCEs, CA, DNA damage and normalized the levels of lipid peroxidation by products with increased activities of antioxidants and detoxification agents in DMBA alone treated hamsters. Outcome of the present study revealed that diosgenin has potent anticlastogenic effects on DMBA treated hamsters.

UI MeSH Term Description Entries
D008297 Male Males
D008647 Mesocricetus A genus in the order Rodentia and family Cricetidae. One species, Mesocricetus auratus or golden hamster is widely used in biomedical research. Hamsters, Golden,Hamsters, Golden Syrian,Hamsters, Syrian,Mesocricetus auratus,Syrian Golden Hamster,Syrian Hamster,Golden Hamster,Golden Hamster, Syrian,Golden Hamsters,Golden Syrian Hamsters,Hamster, Golden,Hamster, Syrian,Hamster, Syrian Golden,Syrian Hamsters
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D001854 Bone Marrow Cells Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells. Bone Marrow Cell,Cell, Bone Marrow,Cells, Bone Marrow,Marrow Cell, Bone,Marrow Cells, Bone
D002869 Chromosome Aberrations Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS. Autosome Abnormalities,Cytogenetic Aberrations,Abnormalities, Autosome,Abnormalities, Chromosomal,Abnormalities, Chromosome,Chromosomal Aberrations,Chromosome Abnormalities,Cytogenetic Abnormalities,Aberration, Chromosomal,Aberration, Chromosome,Aberration, Cytogenetic,Aberrations, Chromosomal,Aberrations, Chromosome,Aberrations, Cytogenetic,Abnormalities, Cytogenetic,Abnormality, Autosome,Abnormality, Chromosomal,Abnormality, Chromosome,Abnormality, Cytogenetic,Autosome Abnormality,Chromosomal Aberration,Chromosomal Abnormalities,Chromosomal Abnormality,Chromosome Aberration,Chromosome Abnormality,Cytogenetic Aberration,Cytogenetic Abnormality
D004144 Diosgenin A spirostan found in DIOSCOREA and other plants. The 25S isomer is called yamogenin. Solasodine is a natural derivative formed by replacing the spiro-ring with a nitrogen, which can rearrange to SOLANINE.
D004249 DNA Damage Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS. DNA Injury,DNA Lesion,DNA Lesions,Genotoxic Stress,Stress, Genotoxic,Injury, DNA,DNA Injuries
D004336 Drug Antagonism Phenomena and pharmaceutics of compounds that inhibit the function of agonists (DRUG AGONISM) and inverse agonists (DRUG INVERSE AGONISM) for a specific receptor. On their own, antagonists produce no effect by themselves to a receptor, and are said to have neither intrinsic activity nor efficacy. Antagonism, Drug,Antagonisms, Drug,Drug Antagonisms
D006224 Cricetinae A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS. Cricetus,Hamsters,Hamster
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

K Rajalingam, and G Sugunadevi, and M A Vijayaanand, and J Sathiyapriya, and K Sivakumar, and K Suresh
September 2011, International journal of oncology,
K Rajalingam, and G Sugunadevi, and M A Vijayaanand, and J Sathiyapriya, and K Sivakumar, and K Suresh
October 1978, Cancer research,
K Rajalingam, and G Sugunadevi, and M A Vijayaanand, and J Sathiyapriya, and K Sivakumar, and K Suresh
June 1978, The Journal of surgical research,
K Rajalingam, and G Sugunadevi, and M A Vijayaanand, and J Sathiyapriya, and K Sivakumar, and K Suresh
January 1985, Nihon Sanka Fujinka Gakkai zasshi,
K Rajalingam, and G Sugunadevi, and M A Vijayaanand, and J Sathiyapriya, and K Sivakumar, and K Suresh
January 1978, The Journal of organic chemistry,
K Rajalingam, and G Sugunadevi, and M A Vijayaanand, and J Sathiyapriya, and K Sivakumar, and K Suresh
September 2001, The Journal of surgical research,
K Rajalingam, and G Sugunadevi, and M A Vijayaanand, and J Sathiyapriya, and K Sivakumar, and K Suresh
August 1979, Chemico-biological interactions,
K Rajalingam, and G Sugunadevi, and M A Vijayaanand, and J Sathiyapriya, and K Sivakumar, and K Suresh
April 1974, Journal of the National Cancer Institute,
K Rajalingam, and G Sugunadevi, and M A Vijayaanand, and J Sathiyapriya, and K Sivakumar, and K Suresh
January 1968, Voprosy onkologii,
K Rajalingam, and G Sugunadevi, and M A Vijayaanand, and J Sathiyapriya, and K Sivakumar, and K Suresh
October 2004, Revista do Hospital das Clinicas,
Copied contents to your clipboard!