Microstructural magnetic resonance imaging of cortical lesions in multiple sclerosis. 2013

M Filippi, and P Preziosa, and E Pagani, and M Copetti, and S Mesaros, and B Colombo, and M A Horsfield, and A Falini, and G Comi, and H Lassmann, and M A Rocca
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan 20132, Italy. m.filippi@hsr.it

BACKGROUND Pathologic and magnetic resonance imaging (MRI) studies have shown that cortical lesions (CLs) are a frequent finding in multiple sclerosis (MS). OBJECTIVE To quantify microstructural damage in CLs and normal appearing (NA) cortex in relapse-onset MS patients at different stages of the disease. METHODS Brain double inversion recovery (DIR), diffusion tensor (DT) MRI and 3D T 1-weighted scans were acquired from 35 relapsing-remitting (RR) patients, 23 secondary progressive (SP) patients, 12 benign (B) MS patients and 41 healthy controls (HC). Diffusivity values in CLs, cortex, white matter (WM) lesions and normal-appearing white matter (NAWM) were assessed. RESULTS Compared to HC, MS patients had a significantly lower fractional anisotropy (FA) and higher mean diffusivity (MD) in the cortex and NAWM. CLs had higher FA vs HC cortex and vs patients' cortex. Compared to RRMS patients, SPMS patients had higher WM lesion volume, higher MD in the cortex, and more severe damage to the NAWM and WM lesions. Compared to SPMS patients, BMS patients had lower MD and FA of CLs. Damage in other compartments was similar between SPMS and BMS patients. Damage in CLs had a high power to discriminate BMS from SPMS (area under the curve: 79-91%), with high specificity (85%), sensitivity (100%) and accuracy (90%). CONCLUSIONS Microstructural imaging features of CLs differ from those of WM lesions and are likely to reflect neuronal damage and microglial activation. The nature and extent of CL damage can be used to help distinguish the different MS clinical phenotypes.

UI MeSH Term Description Entries
D007090 Image Interpretation, Computer-Assisted Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease. Image Interpretation, Computer Assisted,Computer-Assisted Image Interpretation,Computer-Assisted Image Interpretations,Image Interpretations, Computer-Assisted,Interpretation, Computer-Assisted Image,Interpretations, Computer-Assisted Image
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009103 Multiple Sclerosis An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) MS (Multiple Sclerosis),Multiple Sclerosis, Acute Fulminating,Sclerosis, Disseminated,Disseminated Sclerosis,Sclerosis, Multiple
D009413 Nerve Fibers, Myelinated A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves. A Fibers,B Fibers,Fiber, Myelinated Nerve,Fibers, Myelinated Nerve,Myelinated Nerve Fiber,Myelinated Nerve Fibers,Nerve Fiber, Myelinated
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

M Filippi, and P Preziosa, and E Pagani, and M Copetti, and S Mesaros, and B Colombo, and M A Horsfield, and A Falini, and G Comi, and H Lassmann, and M A Rocca
July 2010, Archives of neurology,
M Filippi, and P Preziosa, and E Pagani, and M Copetti, and S Mesaros, and B Colombo, and M A Horsfield, and A Falini, and G Comi, and H Lassmann, and M A Rocca
November 1986, Rinsho shinkeigaku = Clinical neurology,
M Filippi, and P Preziosa, and E Pagani, and M Copetti, and S Mesaros, and B Colombo, and M A Horsfield, and A Falini, and G Comi, and H Lassmann, and M A Rocca
April 1987, The Nebraska medical journal,
M Filippi, and P Preziosa, and E Pagani, and M Copetti, and S Mesaros, and B Colombo, and M A Horsfield, and A Falini, and G Comi, and H Lassmann, and M A Rocca
January 2012, Multiple sclerosis international,
M Filippi, and P Preziosa, and E Pagani, and M Copetti, and S Mesaros, and B Colombo, and M A Horsfield, and A Falini, and G Comi, and H Lassmann, and M A Rocca
September 1987, Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes,
M Filippi, and P Preziosa, and E Pagani, and M Copetti, and S Mesaros, and B Colombo, and M A Horsfield, and A Falini, and G Comi, and H Lassmann, and M A Rocca
March 2010, Annals of neurology,
M Filippi, and P Preziosa, and E Pagani, and M Copetti, and S Mesaros, and B Colombo, and M A Horsfield, and A Falini, and G Comi, and H Lassmann, and M A Rocca
March 2010, Brain : a journal of neurology,
M Filippi, and P Preziosa, and E Pagani, and M Copetti, and S Mesaros, and B Colombo, and M A Horsfield, and A Falini, and G Comi, and H Lassmann, and M A Rocca
May 2001, Archives of neurology,
M Filippi, and P Preziosa, and E Pagani, and M Copetti, and S Mesaros, and B Colombo, and M A Horsfield, and A Falini, and G Comi, and H Lassmann, and M A Rocca
April 1989, Journal of neurology, neurosurgery, and psychiatry,
M Filippi, and P Preziosa, and E Pagani, and M Copetti, and S Mesaros, and B Colombo, and M A Horsfield, and A Falini, and G Comi, and H Lassmann, and M A Rocca
December 1990, No to shinkei = Brain and nerve,
Copied contents to your clipboard!