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The pharmacokinetics of ciprofloxacin were evaluated in 11 patients (3 patients with impaired renal function) with advanced liver cirrhosis after a single oral dose of 500 mg. Mean serum peaks were 2.80 +/- 1.00 mg/l in 64 +/- 37 min after intake in patients with normal renal function. Elimination was reduced in comparison with healthy volunteers: t1/2 beta 510 +/- 158 min with a total area under the curve of 18.2 +/- 10.3 mg x h/l. Mean recovery of the parent compound from urine was 38 +/- 9% of the dose. In 3 patients with cirrhosis plus poor renal function, elimination was markedly reduced. In patients under 60 years with good renal function, the standard does not require a reduction.
M Ruhnke, and
M Trautmann, and
K Borner, and
W Hopfenmüller
January 2002,
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology,
M Ruhnke, and
M Trautmann, and
K Borner, and
W Hopfenmüller
January 1977,
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
M Ruhnke, and
M Trautmann, and
K Borner, and
W Hopfenmüller
January 1989,
International journal of clinical pharmacology research,
M Ruhnke, and
M Trautmann, and
K Borner, and
W Hopfenmüller
January 1982,
Giornale italiano di chemioterapia,
M Ruhnke, and
M Trautmann, and
K Borner, and
W Hopfenmüller
January 2002,
Acta medica Austriaca,
M Ruhnke, and
M Trautmann, and
K Borner, and
W Hopfenmüller
June 1989,
Clinical pharmacology and therapeutics,
M Ruhnke, and
M Trautmann, and
K Borner, and
W Hopfenmüller
March 1992,
Antimicrobial agents and chemotherapy,
M Ruhnke, and
M Trautmann, and
K Borner, and
W Hopfenmüller
June 1982,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
M Ruhnke, and
M Trautmann, and
K Borner, and
W Hopfenmüller
November 1978,
British journal of anaesthesia,
M Ruhnke, and
M Trautmann, and
K Borner, and
W Hopfenmüller
January 1989,
Chemotherapy,
