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Male Sprague-Dawley rats were treated with triiodothyronine (100 micrograms/100 g/day) for 2, 4, 7, 14 and 21 days and the biochemical and ultrastructural changes of the brown adipose tissue were investigated. Results showed that the tissue weight, DNA and phospholipid content increased very early (by day 2 or 4) and that triglycerides increased later. These hormonal effects are not inhibited by the beta 1-antagonist propranolol. From the morphological point of view, triiodothyronine administration induced the early proliferation and maturation of adipocyte precursors (interstitial cells and preadipocytes). It is concluded that triiodothyronine administration causes a very early hyperplasia in the brown adipose tissue similar to that observed during exposure to cold by mechanisms that may not be secondary to the involvement of norepinephrine.
M Masini, and
V De Tata, and
A Del Roso, and
I Simonetti, and
M Pollera, and
E Bergamini
February 1970,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
M Masini, and
V De Tata, and
A Del Roso, and
I Simonetti, and
M Pollera, and
E Bergamini
January 1989,
The International journal of biochemistry,
M Masini, and
V De Tata, and
A Del Roso, and
I Simonetti, and
M Pollera, and
E Bergamini
April 1982,
The Journal of clinical endocrinology and metabolism,
M Masini, and
V De Tata, and
A Del Roso, and
I Simonetti, and
M Pollera, and
E Bergamini
August 1985,
European journal of pharmacology,
M Masini, and
V De Tata, and
A Del Roso, and
I Simonetti, and
M Pollera, and
E Bergamini
May 1985,
Bollettino della Societa italiana di biologia sperimentale,
M Masini, and
V De Tata, and
A Del Roso, and
I Simonetti, and
M Pollera, and
E Bergamini
January 1964,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
M Masini, and
V De Tata, and
A Del Roso, and
I Simonetti, and
M Pollera, and
E Bergamini
January 1979,
Hormone research,
M Masini, and
V De Tata, and
A Del Roso, and
I Simonetti, and
M Pollera, and
E Bergamini
January 1966,
Zeitschrift fur Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948),
M Masini, and
V De Tata, and
A Del Roso, and
I Simonetti, and
M Pollera, and
E Bergamini
November 1969,
Journal of ultrastructure research,
M Masini, and
V De Tata, and
A Del Roso, and
I Simonetti, and
M Pollera, and
E Bergamini
November 1969,
Journal of ultrastructure research,
