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Understanding the basic virology of rotavirus infections has been hampered by the fastidiousness of most isolates and by the lack of a rapid quantitative assay method. The growth characteristics of the simian rotavirus SA11 were studied because it grows to high titers in tissue culture and infectivity can be quantitated by plaque assay. SA11 replication was analyzed in a variety of primary cell cultures or continuous cell lines derived from both homologous and heterologous hosts. Viral replication was observed in each of the cell cultured examined. The individual cell cultures demonstrated marked variability in their susceptibility to rotavirus infection. The highest titers were obtained with MA104, BSC-1, CV-1, and BGM cells. Observable cytopathic effect was found to correlate with the percentage of infected cells in the culture. This study presents growth curves of the simian rotavirus in a variety of cell cultures.
M K Estes, and
D Y Graham, and
C P Gerba, and
E M Smith
April 2002,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
M K Estes, and
D Y Graham, and
C P Gerba, and
E M Smith
March 1992,
Journal of virology,
M K Estes, and
D Y Graham, and
C P Gerba, and
E M Smith
April 1984,
The Journal of general virology,
M K Estes, and
D Y Graham, and
C P Gerba, and
E M Smith
January 1982,
Journal of virology,
M K Estes, and
D Y Graham, and
C P Gerba, and
E M Smith
July 1988,
Nucleic acids research,
M K Estes, and
D Y Graham, and
C P Gerba, and
E M Smith
January 1991,
Voprosy virusologii,
M K Estes, and
D Y Graham, and
C P Gerba, and
E M Smith
December 1986,
Virus research,
M K Estes, and
D Y Graham, and
C P Gerba, and
E M Smith
March 1989,
Nucleic acids research,
M K Estes, and
D Y Graham, and
C P Gerba, and
E M Smith
March 1988,
Virology,
M K Estes, and
D Y Graham, and
C P Gerba, and
E M Smith
July 1982,
Microbiologica,
