-transparent.png){kind=logo}
Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine. 1990
Department of Neurology, King's College Hospital, London, United Kingdom.
Cerebrospinal fluid (CSF) S-adenosylmethionine (SAM) levels were significantly lower in severely depressed patients than in a neurological control group. The administration of SAM either intravenously or orally is associated with a significant rise of CSF SAM, indicating that it crosses the blood-brain barrier in humans. These observations provide a rational basis for the antidepressant effect of SAM, which has been confirmed in several countries. CSF SAM levels were low in a group of patients with Alzheimer's dementia suggesting a possible disturbance of methylation in such patients and the need for trials of SAM treatment.
Related Publications
T Bottiglieri, and
P Godfrey, and
T Flynn, and
M W Carney, and
B K Toone, and
E H Reynolds
September 1995,
Neurology,
T Bottiglieri, and
P Godfrey, and
T Flynn, and
M W Carney, and
B K Toone, and
E H Reynolds
October 1990,
Biochemical medicine and metabolic biology,
T Bottiglieri, and
P Godfrey, and
T Flynn, and
M W Carney, and
B K Toone, and
E H Reynolds
November 1979,
The Journal of antimicrobial chemotherapy,
T Bottiglieri, and
P Godfrey, and
T Flynn, and
M W Carney, and
B K Toone, and
E H Reynolds
January 1988,
Neuroscience and biobehavioral reviews,
T Bottiglieri, and
P Godfrey, and
T Flynn, and
M W Carney, and
B K Toone, and
E H Reynolds
January 2010,
Neuro-degenerative diseases,
T Bottiglieri, and
P Godfrey, and
T Flynn, and
M W Carney, and
B K Toone, and
E H Reynolds
April 2002,
Australian family physician,
T Bottiglieri, and
P Godfrey, and
T Flynn, and
M W Carney, and
B K Toone, and
E H Reynolds
October 2001,
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology,
T Bottiglieri, and
P Godfrey, and
T Flynn, and
M W Carney, and
B K Toone, and
E H Reynolds
January 1994,
Acta neurologica Scandinavica. Supplementum,
T Bottiglieri, and
P Godfrey, and
T Flynn, and
M W Carney, and
B K Toone, and
E H Reynolds
March 1984,
The American journal of psychiatry,
T Bottiglieri, and
P Godfrey, and
T Flynn, and
M W Carney, and
B K Toone, and
E H Reynolds
September 1988,
The American journal of psychiatry,
