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We have observed the influences of opioid-like substances in preoptic area (POA) on the electric activities of pain response neurons in parafascicular nucleus of thalamus (Pf). The results were as follows: 1. Morphine 10 micrograms/microliters or 1 micrograms/microliters microinjected into POA could remarkably inhibit the pain discharges of most (20/26, 19/23 respectively) pain excitatory neurons (PEN) in Pf. The frequency of evoked discharges was decreased nd the duration was shortened. After injecting 10 micrograms/microliters morphine, three neurons showed inhibitory responses to noxious stimuli. 2. Morphine of the two doses could shorten the complete inhibitory period of pain inhibitory neurons (PIN, 23/33). These results suggest that the opioid-like substances in POA might have an inhibitory effects on pain response neurons in Pf.
L J Zhang, and
T Xu
March 1990,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
L J Zhang, and
T Xu
July 1990,
Brain research,
L J Zhang, and
T Xu
January 2017,
Veterinary research forum : an international quarterly journal,
L J Zhang, and
T Xu
January 1991,
Zhen ci yan jiu = Acupuncture research,
L J Zhang, and
T Xu
August 1998,
Brain research,
L J Zhang, and
T Xu
February 2009,
Neuroscience letters,
L J Zhang, and
T Xu
March 1988,
Brain research,
L J Zhang, and
T Xu
January 1991,
Neirofiziologiia = Neurophysiology,
L J Zhang, and
T Xu
August 1988,
Sheng li xue bao : [Acta physiologica Sinica],
L J Zhang, and
T Xu
January 1991,
Zhen ci yan jiu = Acupuncture research,
