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The effects of surgery on TSH secretion, with particular regard to the nocturnal TSH surge, were evaluated in 10 consecutive patients followed for 6 days after surgery. Surgical trauma was associated in all patients with significant decreases in serum total and free T3 and a significant increase in serum rT3 levels, with no variations in serum total and free T4 concentrations. A marked increase in serum cortisol levels was observed, with higher values at night than in the morning. Serum cortisol levels and circadian rhythm normalized on the fifth day. Serum TSH values in the morning significantly decreased on the first day after surgery and returned to normal on the second day. Serum TSH values at night (2400-0200 h) were higher than in the morning preoperatively, but the nocturnal surge was abolished from days 1-5 after surgery and was restored only on the sixth day. Thus, surgery was associated with a prolonged loss of the nocturnal serum TSH surge. This effect on TSH secretion was more marked than predictable on the basis of serum TSH measurements in the morning alone. An inverse relationship was found between serum cortisol and serum TSH values at night, suggesting that the excessive endogenous cortisol secretion might play a role in the derangement of TSH secretion.
L Bartalena, and
E Martino, and
L S Brandi, and
M Falcone, and
A Pacchiarotti, and
C Ricci, and
F Bogazzi, and
L Grasso, and
C Mammoli, and
A Pinchera
September 2002,
Journal of investigative medicine : the official publication of the American Federation for Clinical Research,
L Bartalena, and
E Martino, and
L S Brandi, and
M Falcone, and
A Pacchiarotti, and
C Ricci, and
F Bogazzi, and
L Grasso, and
C Mammoli, and
A Pinchera
May 1986,
The Journal of clinical endocrinology and metabolism,
L Bartalena, and
E Martino, and
L S Brandi, and
M Falcone, and
A Pacchiarotti, and
C Ricci, and
F Bogazzi, and
L Grasso, and
C Mammoli, and
A Pinchera
January 1990,
The Journal of clinical endocrinology and metabolism,
L Bartalena, and
E Martino, and
L S Brandi, and
M Falcone, and
A Pacchiarotti, and
C Ricci, and
F Bogazzi, and
L Grasso, and
C Mammoli, and
A Pinchera
August 1992,
The Journal of pediatrics,
L Bartalena, and
E Martino, and
L S Brandi, and
M Falcone, and
A Pacchiarotti, and
C Ricci, and
F Bogazzi, and
L Grasso, and
C Mammoli, and
A Pinchera
June 1990,
The Journal of clinical endocrinology and metabolism,
L Bartalena, and
E Martino, and
L S Brandi, and
M Falcone, and
A Pacchiarotti, and
C Ricci, and
F Bogazzi, and
L Grasso, and
C Mammoli, and
A Pinchera
January 1986,
Journal of pineal research,
L Bartalena, and
E Martino, and
L S Brandi, and
M Falcone, and
A Pacchiarotti, and
C Ricci, and
F Bogazzi, and
L Grasso, and
C Mammoli, and
A Pinchera
January 1999,
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association,
L Bartalena, and
E Martino, and
L S Brandi, and
M Falcone, and
A Pacchiarotti, and
C Ricci, and
F Bogazzi, and
L Grasso, and
C Mammoli, and
A Pinchera
December 2023,
Science (New York, N.Y.),
L Bartalena, and
E Martino, and
L S Brandi, and
M Falcone, and
A Pacchiarotti, and
C Ricci, and
F Bogazzi, and
L Grasso, and
C Mammoli, and
A Pinchera
December 2020,
The Annals of thoracic surgery,
L Bartalena, and
E Martino, and
L S Brandi, and
M Falcone, and
A Pacchiarotti, and
C Ricci, and
F Bogazzi, and
L Grasso, and
C Mammoli, and
A Pinchera
October 1988,
Neuroendocrinology,
