Comparing dose in the build-up region between compensator- and MLC-based IMRT. 2012

Khosrow Javedan, and Geoffrey G Zhang, and Sarah Hoffe, and Vladimir Feygelman, and Kenneth Forster
Radiation Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA.

The build-up dose in the megavoltage photon beams can be a limiting factor in intensity-modulated radiation therapy (IMRT) treatments. Excessive surface dose can cause patient discomfort and treatment interruptions, while underdosing may lead to tumor repopulation and local failure. Dose in the build-up region was investigated for IMRT delivery with solid brass compensator technique(compensator-based IMRT) and compared with that of multileaf collimator (MLC)-based IMRT. A Varian Trilogy linear accelerator equipped with an MLC was used for beam delivery. A special solid brass step-wise compensator was designed and built for testing purposes. Two step-and-shoot MLC fields were programmed to produce a similar modulated step-wise dose profile. The MLC and compensator dose profiles were measured and adjusted to match at the isocenter depth of 10 cm. Build-up dose in the 1-5 mm depth range was measured with an ultrathin window, fixed volume parallel plate ionization chamber. Monte Carlo simulations were used to model the brass compensator and step-and-shoot MLC fields. The measured and simulated profiles for the two IMRT techniques were matched at the isocenter depth of 10 cm. Different component contributions to the shallow dose, including the MLC scatter, were quantified. Mean spectral energies for the open and filtered beams were calculated. The compensator and MLC profiles at 10 cm depth were matched better than ± 1.5%. The build-up dose was up to 7% lower for compensator IMRT compared to MLC IMRT due to beam hardening in the brass. Low-energy electrons contribute 22% and 15% dose at 1 mm depth for compensator and MLC modalities, respectively. Compensator-based IMRT delivers less dose in the build-up region than MLC-based IMRT does, even though a compensator is closer to the skin than the MLC.

UI MeSH Term Description Entries
D008962 Models, Theoretical Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment. Experimental Model,Experimental Models,Mathematical Model,Model, Experimental,Models (Theoretical),Models, Experimental,Models, Theoretic,Theoretical Study,Mathematical Models,Model (Theoretical),Model, Mathematical,Model, Theoretical,Models, Mathematical,Studies, Theoretical,Study, Theoretical,Theoretical Model,Theoretical Models,Theoretical Studies
D010315 Particle Accelerators Devices which accelerate electrically charged atomic or subatomic particles, such as electrons, protons or ions, to high velocities so they have high kinetic energy. Betatrons,Linear Accelerators,Accelerator, Linear,Accelerator, Particle,Accelerators, Linear,Accelerators, Particle,Betatron,Linear Accelerator,Particle Accelerator
D011879 Radiotherapy Dosage The total amount of radiation absorbed by tissues as a result of radiotherapy. Dosage, Radiotherapy,Dosages, Radiotherapy,Radiotherapy Dosages
D011880 Radiotherapy Planning, Computer-Assisted Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy. Computer-Assisted Radiotherapy Planning,Dosimetry Calculations, Computer-Assisted,Planning, Computer-Assisted Radiotherapy,Calculation, Computer-Assisted Dosimetry,Calculations, Computer-Assisted Dosimetry,Computer Assisted Radiotherapy Planning,Computer-Assisted Dosimetry Calculation,Computer-Assisted Dosimetry Calculations,Dosimetry Calculation, Computer-Assisted,Dosimetry Calculations, Computer Assisted,Planning, Computer Assisted Radiotherapy,Radiotherapy Planning, Computer Assisted
D003198 Computer Simulation Computer-based representation of physical systems and phenomena such as chemical processes. Computational Modeling,Computational Modelling,Computer Models,In silico Modeling,In silico Models,In silico Simulation,Models, Computer,Computerized Models,Computer Model,Computer Simulations,Computerized Model,In silico Model,Model, Computer,Model, Computerized,Model, In silico,Modeling, Computational,Modeling, In silico,Modelling, Computational,Simulation, Computer,Simulation, In silico,Simulations, Computer
D004583 Electrons Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS. Fast Electrons,Negatrons,Positrons,Electron,Electron, Fast,Electrons, Fast,Fast Electron,Negatron,Positron
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D017785 Photons Discrete concentrations of energy, apparently massless elementary particles, that move at the speed of light. They are the unit or quantum of electromagnetic radiation. Photons are emitted when electrons move from one energy state to another. (From Hawley's Condensed Chemical Dictionary, 11th ed)
D050397 Radiotherapy, Intensity-Modulated CONFORMAL RADIOTHERAPY that combines several intensity-modulated beams to provide improved dose homogeneity and highly conformal dose distributions. Helical Tomotherapy,Intensity-Modulated Arc Therapy,Volumetric-Modulated Arc Therapy,Arc Therapies, Intensity-Modulated,Arc Therapies, Volumetric-Modulated,Arc Therapy, Intensity-Modulated,Arc Therapy, Volumetric-Modulated,Helical Tomotherapies,Intensity Modulated Arc Therapy,Intensity-Modulated Arc Therapies,Intensity-Modulated Radiotherapies,Intensity-Modulated Radiotherapy,Radiotherapies, Intensity-Modulated,Radiotherapy, Intensity Modulated,Therapies, Intensity-Modulated Arc,Therapies, Volumetric-Modulated Arc,Therapy, Intensity-Modulated Arc,Therapy, Volumetric-Modulated Arc,Tomotherapies, Helical,Tomotherapy, Helical,Volumetric Modulated Arc Therapy,Volumetric-Modulated Arc Therapies

Related Publications

Khosrow Javedan, and Geoffrey G Zhang, and Sarah Hoffe, and Vladimir Feygelman, and Kenneth Forster
January 2017, Journal of applied clinical medical physics,
Khosrow Javedan, and Geoffrey G Zhang, and Sarah Hoffe, and Vladimir Feygelman, and Kenneth Forster
May 2004, International journal of radiation oncology, biology, physics,
Khosrow Javedan, and Geoffrey G Zhang, and Sarah Hoffe, and Vladimir Feygelman, and Kenneth Forster
October 2017, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Khosrow Javedan, and Geoffrey G Zhang, and Sarah Hoffe, and Vladimir Feygelman, and Kenneth Forster
January 2001, Medical dosimetry : official journal of the American Association of Medical Dosimetrists,
Khosrow Javedan, and Geoffrey G Zhang, and Sarah Hoffe, and Vladimir Feygelman, and Kenneth Forster
January 2001, Medical dosimetry : official journal of the American Association of Medical Dosimetrists,
Khosrow Javedan, and Geoffrey G Zhang, and Sarah Hoffe, and Vladimir Feygelman, and Kenneth Forster
December 2007, Australasian physical & engineering sciences in medicine,
Khosrow Javedan, and Geoffrey G Zhang, and Sarah Hoffe, and Vladimir Feygelman, and Kenneth Forster
April 2001, Physics in medicine and biology,
Khosrow Javedan, and Geoffrey G Zhang, and Sarah Hoffe, and Vladimir Feygelman, and Kenneth Forster
August 2019, Physics in medicine and biology,
Khosrow Javedan, and Geoffrey G Zhang, and Sarah Hoffe, and Vladimir Feygelman, and Kenneth Forster
February 2008, International journal of radiation oncology, biology, physics,
Khosrow Javedan, and Geoffrey G Zhang, and Sarah Hoffe, and Vladimir Feygelman, and Kenneth Forster
January 2017, Nihon Hoshasen Gijutsu Gakkai zasshi,
Copied contents to your clipboard!