This clinical test, concerning the use of tiapride, was carried out for one year on 60 patients, with weekly or bi-mensual check-ups in a neuropsychiatric office, with no other associated medication capable of modifying either vigilance or humor. Tiapride, on top of its excellent tolerance (except for patients presenting a hysterical type structure), and apart from being a sedative for anxiety, turned out to be, on one hand, a disinhibitor for states of depression (even more so when accompanying psychosomatic symptomatology was apparent), and on the other hand a semeiological analyser inasmuch as it can help discern the underlying psychopathological structure.