[Effect of small amounts of methylmercury on embryogenesis and certain biochemical indices]. 1979

A I Shtenberg, and A M Safronova

It was established in experiments on Wistar rats that oral methyl mercuric iodide at doses of 0.85, 0.64, 0.42 and 0.21 mg/kg daily exerts no teratogenic or embryotoxic action on the progeny. However, administration of methyl mercuric iodide at doses of 0.85 and 0.64 mg/kg produced in females a significant decrease in the SH-group content in renal and cerebral tissues, in the activity of acetylcholine esterase in the cerebellum (by 18-48%) and a rise in the activity of glucose-6-phosphatase in the kidneys (by 48-70%). The doses of 0.42 and 0.21 mg/kg administered at various periods of pregnancy, did not exert any effect on the body of females under experimental conditions. These findings are supported to a certain measure by the results of examination of a 2-month progeny of the animals given 0.21 mg/kg methyl mercuric iodide daily. The biochemical parameters of these animals did not differ from those of the control ones.

UI MeSH Term Description Entries
D007454 Iodides Inorganic binary compounds of iodine or the I- ion. Iodide
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D008431 Maternal-Fetal Exchange Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission. Transplacental Exposure,Exchange, Maternal-Fetal,Exposure, Transplacental,Maternal Fetal Exchange
D008767 Methylmercury Compounds Organic compounds in which mercury is attached to a methyl group. Methyl Mercury Compounds,Compounds, Methyl Mercury,Compounds, Methylmercury,Mercury Compounds, Methyl
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D002531 Cerebellum The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills. Cerebella,Corpus Cerebelli,Parencephalon,Cerebellums,Parencephalons
D002795 Choline O-Acetyltransferase An enzyme that catalyzes the formation of acetylcholine from acetyl-CoA and choline. EC 2.3.1.6. Choline Acetylase,Choline Acetyltransferase,Acetylase, Choline,Acetyltransferase, Choline,Choline O Acetyltransferase,O-Acetyltransferase, Choline
D005260 Female Females
D005313 Fetal Death Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH. Fetal Mummification,Fetal Demise,Death, Fetal,Deaths, Fetal,Demise, Fetal,Fetal Deaths,Mummification, Fetal
D005952 Glucose-6-Phosphatase An enzyme that catalyzes the conversion of D-glucose 6-phosphate and water to D-glucose and orthophosphate. EC 3.1.3.9. Glucosephosphatase,Glucose 6-Phosphatase,Glucose-6-Phosphate Phosphohydrolase,Glucose 6 Phosphatase

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