Unitary pattern-based practice is one creative approach to nursing intervention based on the conceptual and theoretical perspective of the Science of Unitary Human Beings. Considerations for practice were derived from the major concepts and theoretical tenets of the framework. Continued clarification and operationalization of the conceptual features in practice is warranted. A template for nursing practice with specified constituents provides a mechanism for implementing practice strategies. Processes of pattern appraisal, deliberative mutual patterning, health patterning, and evaluation were elaborated for the consideration of clinical scholars. Debate and dialogue on these issues is anticipated to further explicate the practice potential of this conceptual system.