Biomaterial Database

Ethical issues of randomized clinical trials. 1990

B A Buck

Joint Center for Radiation Therapy, Boston, Massachusetts 02115.

Randomized clinical trials are an accepted form of experimentation on human subjects to determine the effectiveness of new treatment regimens or drugs. The Declaration of Helsinki, adopted by the World Medical Association, has established guidelines to safeguard humans used as subjects in medical experimentation. The ethical issues of informed consent, the physician-patient relationship and the potential for abuses in research must be considered prior to agreeing to participate in human experimentation.

UI	MeSH Term	Description	Entries
D007258	Informed Consent	Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.	Consent, Informed
D010817	Physician-Patient Relations	The interactions between physician and patient.	Doctor-Patient Relations,Doctor Patient Relations,Physician Patient Relations,Physician Patient Relationship,Doctor Patient Relation,Doctor-Patient Relation,Physician Patient Relation,Physician Patient Relationships,Physician-Patient Relation,Relation, Doctor Patient,Relation, Doctor-Patient,Relation, Physician Patient,Relation, Physician-Patient,Relations, Doctor Patient,Relations, Doctor-Patient,Relations, Physician Patient,Relations, Physician-Patient,Relationship, Physician Patient,Relationships, Physician Patient
D002985	Clinical Protocols	Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy.	Protocols, Clinical,Research Protocols, Clinical,Treatment Protocols,Clinical Protocol,Clinical Research Protocol,Clinical Research Protocols,Protocol, Clinical,Protocol, Clinical Research,Protocols, Clinical Research,Protocols, Treatment,Research Protocol, Clinical,Treatment Protocol
D004992	Ethics, Medical	The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families.	Medical Ethics
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006805	Human Experimentation	The use of humans as investigational subjects.	Human Research Subject Protection,Experimentation, Human
D015871	Scientific Misconduct	Intentional falsification of scientific data by presentation of fraudulent or incomplete or uncorroborated findings as scientific fact.	Ethics in Publishing,Fraud, Scientific,Fraudulent Data,Research Misconduct,Scientific Dishonesty,Data, Fraudulent,Dishonesties, Scientific,Dishonesty, Scientific,Frauds, Scientific,Misconduct, Research,Misconduct, Scientific,Publishing, Ethics in,Scientific Dishonesties,Scientific Fraud,Scientific Frauds
D016032	Randomized Controlled Trials as Topic	Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.	Clinical Trials, Randomized,Controlled Clinical Trials, Randomized,Trials, Randomized Clinical