-transparent.png){kind=logo}
N-Nitrosodimethylamine and 1,2-dimethylhydrazine were shown to injure lethally primary monolayer cultures of rat hepatocytes only after incubation periods in excess of 24 hr. The toxic action of these agents, therefore, mimics the time dependency of their hepatoxicity in vivo. The viability of hepatocytes treated with N-nitrosomethylbenzylamine was not different from controls at times up to 54 hr following treatment, a result which is also consistent with the inability of this compound to produce hepatotoxicity in vivo.
Related Publications
L Catz-Biro, and
W Chin, and
M C Archer, and
M S Pollanen, and
M A Hayes
June 1985,
Carcinogenesis,
L Catz-Biro, and
W Chin, and
M C Archer, and
M S Pollanen, and
M A Hayes
January 1982,
Carcinogenesis,
L Catz-Biro, and
W Chin, and
M C Archer, and
M S Pollanen, and
M A Hayes
August 1982,
Cancer research,
L Catz-Biro, and
W Chin, and
M C Archer, and
M S Pollanen, and
M A Hayes
July 1991,
Carcinogenesis,
L Catz-Biro, and
W Chin, and
M C Archer, and
M S Pollanen, and
M A Hayes
May 1984,
Biochemical pharmacology,
L Catz-Biro, and
W Chin, and
M C Archer, and
M S Pollanen, and
M A Hayes
May 1996,
Carcinogenesis,
L Catz-Biro, and
W Chin, and
M C Archer, and
M S Pollanen, and
M A Hayes
December 1982,
Chemico-biological interactions,
L Catz-Biro, and
W Chin, and
M C Archer, and
M S Pollanen, and
M A Hayes
April 1990,
Experimental and molecular pathology,
L Catz-Biro, and
W Chin, and
M C Archer, and
M S Pollanen, and
M A Hayes
April 1981,
Toxicology and applied pharmacology,
L Catz-Biro, and
W Chin, and
M C Archer, and
M S Pollanen, and
M A Hayes
December 1998,
Toxicology in vitro : an international journal published in association with BIBRA,
