BIOMAT Database Logo BIOMAT Database Logo

Gastric mucosal prostaglandin synthesis in the presence of Campylobacter pylori in patients with gastric ulcers and non-ulcer dyspepsia. 1990

A S Taha, and P Boothman, and P Holland, and A McKinlay, and R Upadhyay, and R W Kelly, and F Lee, and R I Russell
Department of Gastroenterology, Glasgow Royal Infirmary.

It is unclear how Campylobacter pylori (CP) interacts with gastric mucosal prostaglandins (PG). In a double-blind study we measured gastric PG synthesis in 22 patients with benign gastric antral ulcers (GU) and 26 with non-ulcer dyspepsis (NUD). CP status was determined by histology and bacteriology: 26 (16 GU plus 10 NUD) were CP positive, and 22 (6 GU plus 16 NUD) were CP negative. Patients with severe gastritis regardless of CP status) had significantly higher PGE2 and PGI2 values than those with mild gastritis. Severe gastritis was found in 36% of CP-negative subjects and 77% of the CP-positive patients (chi 2 = 8.64, p less than 0.01), but no significant differences in PG values were found between CP-positive or -negative patients.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011453 Prostaglandins A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes. Prostaglandin,Prostanoid,Prostanoids
D002169 Campylobacter Infections Infections with bacteria of the genus CAMPYLOBACTER. Campylobacter Infection,Campylobacteriosis,Infections, Campylobacter,Campylobacterioses,Infection, Campylobacter
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D004415 Dyspepsia Impaired digestion, especially after eating. Indigestion,Dyspepsias,Indigestions
D005260 Female Females
D005753 Gastric Mucosa Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones. Cardiac Glands,Gastric Glands,Pyloric Glands,Cardiac Gland,Gastric Gland,Gastric Mucosas,Gland, Cardiac,Gland, Gastric,Gland, Pyloric,Glands, Cardiac,Glands, Gastric,Glands, Pyloric,Mucosa, Gastric,Mucosas, Gastric,Pyloric Gland
D005756 Gastritis Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders. Gastritides
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

A S Taha, and P Boothman, and P Holland, and A McKinlay, and R Upadhyay, and R W Kelly, and F Lee, and R I Russell
[Presence of Campylobacter pylori in the gastric mucosa of healthy persons and in patients with peptic ulcer and non-ulcer dyspepsia].
August 1988, Polski tygodnik lekarski (Warsaw, Poland : 1960),
A S Taha, and P Boothman, and P Holland, and A McKinlay, and R Upadhyay, and R W Kelly, and F Lee, and R I Russell
Campylobacter pylori and non-ulcer dyspepsia.
November 1987, The American journal of gastroenterology,
A S Taha, and P Boothman, and P Holland, and A McKinlay, and R Upadhyay, and R W Kelly, and F Lee, and R I Russell
[Non-ulcer dyspepsia and Campylobacter pylori].
June 1989, Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
A S Taha, and P Boothman, and P Holland, and A McKinlay, and R Upadhyay, and R W Kelly, and F Lee, and R I Russell
Isolation of Campylobacter pylori in patients with non-ulcer dyspepsia.
July 1989, Journal of chemotherapy (Florence, Italy),
A S Taha, and P Boothman, and P Holland, and A McKinlay, and R Upadhyay, and R W Kelly, and F Lee, and R I Russell
Campylobacter pylori--a role in non-ulcer dyspepsia?
January 1989, Scandinavian journal of gastroenterology. Supplement,
A S Taha, and P Boothman, and P Holland, and A McKinlay, and R Upadhyay, and R W Kelly, and F Lee, and R I Russell
[Campylobacter pylori, ulcer and dyspepsia].
November 1988, Deutsche medizinische Wochenschrift (1946),
A S Taha, and P Boothman, and P Holland, and A McKinlay, and R Upadhyay, and R W Kelly, and F Lee, and R I Russell
Campylobacter pylori, non-ulcer dyspepsia, and race in Malaysia.
May 1989, Lancet (London, England),
A S Taha, and P Boothman, and P Holland, and A McKinlay, and R Upadhyay, and R W Kelly, and F Lee, and R I Russell
Prostaglandin and Helicobacter pylori-related non-ulcer dyspepsia.
December 1991, The American journal of gastroenterology,
A S Taha, and P Boothman, and P Holland, and A McKinlay, and R Upadhyay, and R W Kelly, and F Lee, and R I Russell
[Endocrine and exocrine gastric mucosal secretion in the course of H. pylori eradication in patients with non-ulcer dyspepsia].
January 1997, Wiadomosci lekarskie (Warsaw, Poland : 1960),
A S Taha, and P Boothman, and P Holland, and A McKinlay, and R Upadhyay, and R W Kelly, and F Lee, and R I Russell
Campylobacter associated gastritis in patients with non-ulcer dyspepsia.
January 1988, Journal of clinical pathology,
Copied contents to your clipboard!