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Host factors have been given scant attention in the search for etiology in pancreatic cancer. Several anecdotal reports have identified its familial clustering, whereas a recent population-based case/control study has shown that 6.7% of cases and 0.7% of controls had positive family histories of this disease (p less than 0.001). Forty-seven individuals with pancreatic cancer from 18 families were identified from a review of the medical records of all kindreds on file at our Hereditary Cancer Institute. The observed sex ratio, age of onset, histologic type, and survival were comparable to published data on unselected patients. We did not identify any pattern of extra-pancreatic cancer association. A serious limitation of our study is its lack of a population-based case/control design. Whereas our data are primarily descriptive, they do indicate the need to learn more about the role of familial factors in the etiology of pancreatic cancer. Pancreatic cancer is increasing in incidence, and its prognosis is almost uniformly dismal; identification of persons at high risk may improve cancer control.
H T Lynch, and
M L Fitzsimmons, and
T C Smyrk, and
S J Lanspa, and
P Watson, and
J McClellan, and
J F Lynch
January 1997,
Acta gastro-enterologica Belgica,
H T Lynch, and
M L Fitzsimmons, and
T C Smyrk, and
S J Lanspa, and
P Watson, and
J McClellan, and
J F Lynch
October 2020,
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver,
H T Lynch, and
M L Fitzsimmons, and
T C Smyrk, and
S J Lanspa, and
P Watson, and
J McClellan, and
J F Lynch
November 2010,
Clinical genetics,
H T Lynch, and
M L Fitzsimmons, and
T C Smyrk, and
S J Lanspa, and
P Watson, and
J McClellan, and
J F Lynch
July 2023,
Familial cancer,
H T Lynch, and
M L Fitzsimmons, and
T C Smyrk, and
S J Lanspa, and
P Watson, and
J McClellan, and
J F Lynch
May 2012,
European journal of human genetics : EJHG,
H T Lynch, and
M L Fitzsimmons, and
T C Smyrk, and
S J Lanspa, and
P Watson, and
J McClellan, and
J F Lynch
December 1997,
International journal of pancreatology : official journal of the International Association of Pancreatology,
H T Lynch, and
M L Fitzsimmons, and
T C Smyrk, and
S J Lanspa, and
P Watson, and
J McClellan, and
J F Lynch
April 2007,
PLoS medicine,
H T Lynch, and
M L Fitzsimmons, and
T C Smyrk, and
S J Lanspa, and
P Watson, and
J McClellan, and
J F Lynch
March 2007,
Cancer biology & therapy,
H T Lynch, and
M L Fitzsimmons, and
T C Smyrk, and
S J Lanspa, and
P Watson, and
J McClellan, and
J F Lynch
November 2009,
British journal of cancer,
H T Lynch, and
M L Fitzsimmons, and
T C Smyrk, and
S J Lanspa, and
P Watson, and
J McClellan, and
J F Lynch
January 1989,
European journal of gynaecological oncology,
