Organocatalytic dynamic kinetic resolution via conjugate addition: synthesis of chiral trans-2,5-dialkylcyclohexanones. 2012

Ganesh Pandey, and Priyanka A Adate, and Vedavati G Puranik
Division of Organic Chemistry, National Chemical Laboratory, Pune, India. gp.pandey@ncl.res.in

A novel strategy of initiating an organocatalysed dynamic kinetic resolution (dr up to 99 : 1 and er up to 94 : 6) for the synthesis of chiral trans-2,5-dialkylcyclohexanones by an asymmetric conjugate addition of dimethyl malonate on to 6-substituted cyclohexenones is reported.

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