Lignans and triterpenes from the root of Pseuderanthemum carruthersii var. atropurpureum. 2012

Thi Nga Vo, and Phi Linh Nguyen, and Lam Truong Tuong, and Lawrence Michael Pratt, and Phung Nguyen Vo, and Kim Phi Phung Nguyen, and Ngoc Suong Nguyen
Department of Chemical-Food Technology, University of Technical Education-Ho Chi Minh City, 1 Vo Van Ngan Str., Thu Duc Dist., Ho Chi Minh 720059, Vietnam.

Two new lignans, pseuderesinol (1), pseuderanoside (2) and a new triterpene, pseuderanic acid (3) were isolated from the dried root of Pseuderanthemum carruthersii (SEEM.) GUILL. var. atropurpureum (BULL.) FOSB. (Acanthaceae), together with ten known compounds, including five lignans, (+)-eudesmin (4), (+)-magnolin (5), (+)-syringaresinol (6), (+)-episyringaresinol (7), (+)-1-hydroxysyringaresinol (8) and five triterpenes, squalene (9), oleanolic acid (10), lupeol (11), betulin (12), betulinic acid (13). Their chemical structures were elucidated by 1D- and 2D-NMR, computational quantum chemistry, as well as high resolution-electrospray ionization (HR-ESI)-MS spectroscopic analysis. The acetylcholinesterase inhibition and cytotoxic activities against HeLa and MCF-7 cancer cell lines were evaluated on some purified compounds at the concentration of 100 µg/mL. Pseuderesinol (1) and magnolin (5) exhibited moderate cytotoxic activities against the MCF-7 cancer cell line.

UI MeSH Term Description Entries
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000972 Antineoplastic Agents, Phytogenic Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. Antineoplastics, Botanical,Antineoplastics, Phytogenic,Agents, Phytogenic Antineoplastic,Botanical Antineoplastics,Phytogenic Antineoplastic Agents,Phytogenic Antineoplastics
D014315 Triterpenes A class of terpenes (the general formula C30H48) formed by the condensation of six isoprene units, equivalent to three terpene units. Triterpene,Triterpenoid,Triterpenoids
D017705 Lignans A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) Lignan,Neolignan,Neolignans
D045744 Cell Line, Tumor A cell line derived from cultured tumor cells. Tumor Cell Line,Cell Lines, Tumor,Line, Tumor Cell,Lines, Tumor Cell,Tumor Cell Lines
D018517 Plant Roots The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990) Plant Bulbs,Plant Root,Bulb, Plant,Bulbs, Plant,Plant Bulb,Root, Plant,Roots, Plant
D027901 Acanthaceae A plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA. Acanthus,Hypoestes,Ruellia,Thunbergia,Hygrophila

Related Publications

Thi Nga Vo, and Phi Linh Nguyen, and Lam Truong Tuong, and Lawrence Michael Pratt, and Phung Nguyen Vo, and Kim Phi Phung Nguyen, and Ngoc Suong Nguyen
June 2011, Planta medica,
Thi Nga Vo, and Phi Linh Nguyen, and Lam Truong Tuong, and Lawrence Michael Pratt, and Phung Nguyen Vo, and Kim Phi Phung Nguyen, and Ngoc Suong Nguyen
August 2007, Chemical & pharmaceutical bulletin,
Thi Nga Vo, and Phi Linh Nguyen, and Lam Truong Tuong, and Lawrence Michael Pratt, and Phung Nguyen Vo, and Kim Phi Phung Nguyen, and Ngoc Suong Nguyen
October 2010, Journal of natural products,
Thi Nga Vo, and Phi Linh Nguyen, and Lam Truong Tuong, and Lawrence Michael Pratt, and Phung Nguyen Vo, and Kim Phi Phung Nguyen, and Ngoc Suong Nguyen
May 2015, Journal of Asian natural products research,
Thi Nga Vo, and Phi Linh Nguyen, and Lam Truong Tuong, and Lawrence Michael Pratt, and Phung Nguyen Vo, and Kim Phi Phung Nguyen, and Ngoc Suong Nguyen
January 2012, Journal of Asian natural products research,
Thi Nga Vo, and Phi Linh Nguyen, and Lam Truong Tuong, and Lawrence Michael Pratt, and Phung Nguyen Vo, and Kim Phi Phung Nguyen, and Ngoc Suong Nguyen
December 1998, Journal of natural products,
Thi Nga Vo, and Phi Linh Nguyen, and Lam Truong Tuong, and Lawrence Michael Pratt, and Phung Nguyen Vo, and Kim Phi Phung Nguyen, and Ngoc Suong Nguyen
December 2005, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Thi Nga Vo, and Phi Linh Nguyen, and Lam Truong Tuong, and Lawrence Michael Pratt, and Phung Nguyen Vo, and Kim Phi Phung Nguyen, and Ngoc Suong Nguyen
August 2005, Journal of natural products,
Thi Nga Vo, and Phi Linh Nguyen, and Lam Truong Tuong, and Lawrence Michael Pratt, and Phung Nguyen Vo, and Kim Phi Phung Nguyen, and Ngoc Suong Nguyen
February 2012, Journal of agricultural and food chemistry,
Thi Nga Vo, and Phi Linh Nguyen, and Lam Truong Tuong, and Lawrence Michael Pratt, and Phung Nguyen Vo, and Kim Phi Phung Nguyen, and Ngoc Suong Nguyen
May 2022, Natural products and bioprospecting,
Copied contents to your clipboard!