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In 16 patients with acute myocardial infarction and in 15 controls, procollagen type III aminoterminal peptide in serum (PIIINP) was measured consecutively. Serum PIIINP was increased on the second to third postinfarction day (p less than 0.01) and remained elevated for more than 4 months. Peak values were observed on the third to seventh postinfarction day. The individual peak changes were correlated to infarction size calculated from serum CK-MB and serum lactate dehydrogenase (p = 0.60, p = 0.02). The changes in distribution of PIIINP-related antigens in serum after gel chromatography were similar to changes observed during wound healing in humans. PIIINP is cleaved off procollagen type III during the biosynthesis of type III collagen, which characterizes the early stages of repair and inflammation. Our findings suggest that serum PIIINP reflects the repair processes and scar formation following acute myocardial infarction. The serum PIIINP alterations in acute myocardial infarction differ essentially from the changes in myocardial enzymes reflecting myocardial injury. Serum PIIINP may therefore provide new and clinically relevant information on the healing of myocardial infarction.
L T Jensen, and
K Hørslev-Petersen, and
P Toft, and
K D Bentsen, and
P Grande, and
E E Simonsen, and
I Lorenzen
November 1995,
The American journal of cardiology,
L T Jensen, and
K Hørslev-Petersen, and
P Toft, and
K D Bentsen, and
P Grande, and
E E Simonsen, and
I Lorenzen
December 1983,
American journal of hematology,
L T Jensen, and
K Hørslev-Petersen, and
P Toft, and
K D Bentsen, and
P Grande, and
E E Simonsen, and
I Lorenzen
March 1988,
Clinical rheumatology,
L T Jensen, and
K Hørslev-Petersen, and
P Toft, and
K D Bentsen, and
P Grande, and
E E Simonsen, and
I Lorenzen
May 1992,
Medicina clinica,
L T Jensen, and
K Hørslev-Petersen, and
P Toft, and
K D Bentsen, and
P Grande, and
E E Simonsen, and
I Lorenzen
April 1986,
The British journal of dermatology,
L T Jensen, and
K Hørslev-Petersen, and
P Toft, and
K D Bentsen, and
P Grande, and
E E Simonsen, and
I Lorenzen
December 1996,
Polskie Archiwum Medycyny Wewnetrznej,
L T Jensen, and
K Hørslev-Petersen, and
P Toft, and
K D Bentsen, and
P Grande, and
E E Simonsen, and
I Lorenzen
April 1987,
Liver,
L T Jensen, and
K Hørslev-Petersen, and
P Toft, and
K D Bentsen, and
P Grande, and
E E Simonsen, and
I Lorenzen
June 1990,
British journal of rheumatology,
L T Jensen, and
K Hørslev-Petersen, and
P Toft, and
K D Bentsen, and
P Grande, and
E E Simonsen, and
I Lorenzen
June 1994,
Transplantation proceedings,
L T Jensen, and
K Hørslev-Petersen, and
P Toft, and
K D Bentsen, and
P Grande, and
E E Simonsen, and
I Lorenzen
February 1998,
American heart journal,
