-transparent.png){kind=logo}
The aim of this study was to elucidate the effect of dietary variations of linoleic acid on the development of deoxycorticosterone acetate (DOCA)-salt hypertension in rats. All rats were divided into three groups and fed one of the following isocaloric diets with 8% NaCl: a high linoleic acid (HLA) (20% sunflower oil), a moderate linoleic acid (5% lard oil + 15% sunflower oil), or a low linoleic acid (DLA) (20% lard oil). After 4 weeks of feeding, we determined intraerythrocyte sodium, potassium, and magnesium concentrations, intra-aortic and lymphocyte magnesium content, and erythrocyte ouabain-sensitive 22Na efflux rate constant. Cytoplasmic free calcium concentration of lymphocytes from thymus was also determined with quin-2 as a fluorescent indicator. In the HLA group, the elevation of systolic blood pressure was significantly attenuated, and intraerythrocyte sodium concentration was significantly lower than in the DLA group. There were greater intraerythrocyte potassium and magnesium concentrations, intra-aortic and lymphocyte magnesium contents, and erythrocyte ouabain-sensitive 22Na efflux rate constant in the HLA group as compared with other groups. Cytoplasmic free calcium concentration in the HLA group was significantly lower than in other groups. Systolic blood pressure significantly correlated negatively with intraerythrocyte and intra-aortic magnesium concentrations and intraerythrocyte potassium concentration, and correlated positively with cytoplasmic free calcium concentration. Erythrocyte ouabain-sensitive 22Na efflux rate constant significantly correlated positively with intraerythrocyte magnesium concentration. These findings suggest that dietary linoleic acid can attenuate the development of DOCA-salt hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)
J Kawahara, and
H Sano, and
Y Kubota, and
K Hattori, and
T Miki, and
H Suzuki, and
H Fukuzaki
May 1987,
Canadian journal of physiology and pharmacology,
J Kawahara, and
H Sano, and
Y Kubota, and
K Hattori, and
T Miki, and
H Suzuki, and
H Fukuzaki
January 1994,
Journal of cardiovascular pharmacology,
J Kawahara, and
H Sano, and
Y Kubota, and
K Hattori, and
T Miki, and
H Suzuki, and
H Fukuzaki
February 2013,
Cardiovascular drugs and therapy,
J Kawahara, and
H Sano, and
Y Kubota, and
K Hattori, and
T Miki, and
H Suzuki, and
H Fukuzaki
January 1988,
Pharmacology,
J Kawahara, and
H Sano, and
Y Kubota, and
K Hattori, and
T Miki, and
H Suzuki, and
H Fukuzaki
August 1981,
Canadian journal of physiology and pharmacology,
J Kawahara, and
H Sano, and
Y Kubota, and
K Hattori, and
T Miki, and
H Suzuki, and
H Fukuzaki
January 1994,
Hypertension (Dallas, Tex. : 1979),
J Kawahara, and
H Sano, and
Y Kubota, and
K Hattori, and
T Miki, and
H Suzuki, and
H Fukuzaki
March 1995,
European journal of pharmacology,
J Kawahara, and
H Sano, and
Y Kubota, and
K Hattori, and
T Miki, and
H Suzuki, and
H Fukuzaki
October 1987,
Japanese circulation journal,
J Kawahara, and
H Sano, and
Y Kubota, and
K Hattori, and
T Miki, and
H Suzuki, and
H Fukuzaki
November 1994,
Hypertension (Dallas, Tex. : 1979),
J Kawahara, and
H Sano, and
Y Kubota, and
K Hattori, and
T Miki, and
H Suzuki, and
H Fukuzaki
December 2000,
Journal of hypertension,
