The nursing literature states that reminiscence is an independent nursing intervention for elderly clients and patients. This paper is about the use of reminiscence by nurses in all settings. Nurses have not to date built a firm knowledge base. The paper discusses the need for knowledge about the phenomenon and life review versus reminiscence. The uses of reminiscence therapy in one-to-one interaction, in the group modality, and as a research tool are all important applications of the concept. In contrast to other disciplines, reminiscence therapy, as studied by nurses, focuses on interventions. Reminiscence is a fascinating, elusive, and complex phenomenon, but although nursing textbooks tout its usefulness, the research findings are less optimistic.