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The authors studied clinical response in 47 depressed inpatients treated with the monoamine oxidase (MAO) inhibitor phenelzine. Improvement on ratings for depression at Week 2 of treatment was correlated with percent MAO inhibition at Week 2 (r = .35, p less than .03), and the modest positive correlation that was found remained after the authors adjusted for the effects of baseline scores on the Hamilton Rating Scale for Depression, dose (mg/kg), and psychosis (partial correlation = .49, p less than .002). Further, the 23 patients ultimately classified as responders had a significantly greater percent MAO inhibition at Week 2 than did the 24 nonresponders (t = 3.02, p less than .005). Thus, the rate of MAO inhibition at Week 2 was significantly correlated with clinical improvement at Week 2 and final response status. These findings could not be explained by other potentially moderating variables such as sex, age, endogenicity, recurrence, and incapacitation.
D B Bresnahan, and
G N Pandey, and
P G Janicak, and
R Sharma, and
R A Boshes, and
S S Chang, and
B L Gierl, and
J M Davis
October 1990,
The American journal of psychiatry,
D B Bresnahan, and
G N Pandey, and
P G Janicak, and
R Sharma, and
R A Boshes, and
S S Chang, and
B L Gierl, and
J M Davis
January 1981,
Neuropsychobiology,
D B Bresnahan, and
G N Pandey, and
P G Janicak, and
R Sharma, and
R A Boshes, and
S S Chang, and
B L Gierl, and
J M Davis
January 1960,
Journal of neuropsychiatry,
D B Bresnahan, and
G N Pandey, and
P G Janicak, and
R Sharma, and
R A Boshes, and
S S Chang, and
B L Gierl, and
J M Davis
April 1978,
The American journal of psychiatry,
D B Bresnahan, and
G N Pandey, and
P G Janicak, and
R Sharma, and
R A Boshes, and
S S Chang, and
B L Gierl, and
J M Davis
March 2001,
Archives of general psychiatry,
D B Bresnahan, and
G N Pandey, and
P G Janicak, and
R Sharma, and
R A Boshes, and
S S Chang, and
B L Gierl, and
J M Davis
March 1973,
Lancet (London, England),
D B Bresnahan, and
G N Pandey, and
P G Janicak, and
R Sharma, and
R A Boshes, and
S S Chang, and
B L Gierl, and
J M Davis
April 1985,
The American journal of psychiatry,
D B Bresnahan, and
G N Pandey, and
P G Janicak, and
R Sharma, and
R A Boshes, and
S S Chang, and
B L Gierl, and
J M Davis
January 1977,
Neuropsychobiology,
D B Bresnahan, and
G N Pandey, and
P G Janicak, and
R Sharma, and
R A Boshes, and
S S Chang, and
B L Gierl, and
J M Davis
October 1985,
Clinica chimica acta; international journal of clinical chemistry,
D B Bresnahan, and
G N Pandey, and
P G Janicak, and
R Sharma, and
R A Boshes, and
S S Chang, and
B L Gierl, and
J M Davis
September 1973,
Proceedings of the Royal Society of Medicine,
