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Class Ia molecules of human leucocyte antigen (HLA-A, -B and -C) are widely expressed and play a central role in the immune system by presenting peptides derived from the lumen of the endoplasmic reticulum. In contrast, class Ib molecules such as HLA-G serve novel functions. The distribution of HLA-G is mostly limited to foetal trophoblastic tissues and some tumour tissues. The mechanism required for the tissue-specific regulation of the HLA-G gene has not been well understood. Here, we investigated the genomic regulation of HLA-G by manipulating one copy of a genomic DNA fragment on a human artificial chromosome. We identified a potential negative regulator of gene expression in a sequence upstream of HLA-G that overlapped with the long interspersed element (LINE1); silencing of HLA-G involved a DNA secondary structure generated in LINE1. The presence of a LINE1 gene silencer may explain the limited expression of HLA-G compared with other class I genes.
Masashi Ikeno, and
Nobutaka Suzuki, and
Megumi Kamiya, and
Yuji Takahashi, and
Jun Kudoh, and
Tsuneko Okazaki
August 2012,
The Journal of biological chemistry,
Masashi Ikeno, and
Nobutaka Suzuki, and
Megumi Kamiya, and
Yuji Takahashi, and
Jun Kudoh, and
Tsuneko Okazaki
May 2020,
Infection and immunity,
Masashi Ikeno, and
Nobutaka Suzuki, and
Megumi Kamiya, and
Yuji Takahashi, and
Jun Kudoh, and
Tsuneko Okazaki
September 2012,
FEMS yeast research,
Masashi Ikeno, and
Nobutaka Suzuki, and
Megumi Kamiya, and
Yuji Takahashi, and
Jun Kudoh, and
Tsuneko Okazaki
November 1993,
Tissue antigens,
Masashi Ikeno, and
Nobutaka Suzuki, and
Megumi Kamiya, and
Yuji Takahashi, and
Jun Kudoh, and
Tsuneko Okazaki
October 2012,
Cell death & disease,
Masashi Ikeno, and
Nobutaka Suzuki, and
Megumi Kamiya, and
Yuji Takahashi, and
Jun Kudoh, and
Tsuneko Okazaki
August 2010,
Proceedings of the National Academy of Sciences of the United States of America,
Masashi Ikeno, and
Nobutaka Suzuki, and
Megumi Kamiya, and
Yuji Takahashi, and
Jun Kudoh, and
Tsuneko Okazaki
October 2019,
Immunology,
Masashi Ikeno, and
Nobutaka Suzuki, and
Megumi Kamiya, and
Yuji Takahashi, and
Jun Kudoh, and
Tsuneko Okazaki
March 2006,
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG,
Masashi Ikeno, and
Nobutaka Suzuki, and
Megumi Kamiya, and
Yuji Takahashi, and
Jun Kudoh, and
Tsuneko Okazaki
February 1990,
Journal of bacteriology,
Masashi Ikeno, and
Nobutaka Suzuki, and
Megumi Kamiya, and
Yuji Takahashi, and
Jun Kudoh, and
Tsuneko Okazaki
March 2023,
Mitochondrion,
