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Total skin electron beam radiation in a pediatric patient with leukemia cutis: a case report. 2012

Nazanin K Majd, and Sheena K Jain, and Mike C Murphy, and Joseph P Dugas, and Frederick Hager, and Ramzi Abdulrahman
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9183, USA.

Leukemia cutis, a form of extramedullary leukemia involving the skin, is a poor prognostic marker and indicator of imminent hematologic relapse and chemotherapeutic resistance in leukemia patients. Although total skin electron beam radiotherapy is commonly recommended for patients with leukemia cutis, its role and effectiveness remains unclear. Here we describe a 19-month-old infant with acute myelogenous leukemia first diagnosed at 15 months of age. It relapsed in her skin at 18 months of age, associated with raised hyperpigmented lesions on her chest and scalp. Radiation treatment to the total skin surface with radiation therapy resulted in relief of her symptoms before relapse in the bone marrow.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D011882 Radiotherapy, High-Energy Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle. Megavolt Radiotherapy,High-Energy Radiotherapy,Radiotherapy, Megavolt,High Energy Radiotherapy,Radiotherapy, High Energy
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012878 Skin Neoplasms Tumors or cancer of the SKIN. Cancer of Skin,Skin Cancer,Cancer of the Skin,Neoplasms, Skin,Cancer, Skin,Cancers, Skin,Neoplasm, Skin,Skin Cancers,Skin Neoplasm
D023981 Sarcoma, Myeloid An extramedullary tumor of immature MYELOID CELLS or MYELOBLASTS. Granulocytic sarcoma usually occurs with or follows the onset of ACUTE MYELOID LEUKEMIA. Chloroma,Myeloid Sarcoma,Sarcoma, Granulocytic,Extramedullary Myeloid Cell Tumor,Myeloid Cell Tumor, Extramedullary,Chloromas,Granulocytic Sarcoma,Granulocytic Sarcomas,Myeloid Sarcomas,Sarcomas, Granulocytic,Sarcomas, Myeloid

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