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The effects of total lymphoid irradiation, cyclosporine and splenectomy alone and in combination have been studied in liver transplants from the LVG hamster to the LEW rat. Neither CsA alone, splenectomy alone, nor TLI alone prolonged graft survival. CsA/splenectomy and TLI/CsA produced significant prolongation of graft survival. TLI/CsA/splenectomy prolonged graft survival by over sixfold compared with controls. While CsA alone was ineffective in reducing lymphocytotoxic antidonor antibody, splenectomy alone or CsA/splenectomy did significantly suppress production of antibody. Only very low levels of antibody could be detected in animals treated with TLI/CsA/splenectomy. TLI/CsA/splenectomy has an immunosuppressive effect sufficient to significantly prolong liver graft survival in the LVG hamster to LEW rat combination and may represent a promising treatment protocol in experimental cross-species transplantation.
Y Yamaguchi, and
E C Halperin, and
R C Harland, and
C Wyble, and
R R Bollinger
June 1984,
Transplantation,
Y Yamaguchi, and
E C Halperin, and
R C Harland, and
C Wyble, and
R R Bollinger
March 1990,
Transplantation,
Y Yamaguchi, and
E C Halperin, and
R C Harland, and
C Wyble, and
R R Bollinger
February 1987,
Transplantation proceedings,
Y Yamaguchi, and
E C Halperin, and
R C Harland, and
C Wyble, and
R R Bollinger
September 1987,
Transplantation,
Y Yamaguchi, and
E C Halperin, and
R C Harland, and
C Wyble, and
R R Bollinger
January 1985,
Transplantation,
Y Yamaguchi, and
E C Halperin, and
R C Harland, and
C Wyble, and
R R Bollinger
January 1986,
The Journal of heart transplantation,
Y Yamaguchi, and
E C Halperin, and
R C Harland, and
C Wyble, and
R R Bollinger
February 1987,
Transplantation,
Y Yamaguchi, and
E C Halperin, and
R C Harland, and
C Wyble, and
R R Bollinger
December 1987,
Transplantation,
Y Yamaguchi, and
E C Halperin, and
R C Harland, and
C Wyble, and
R R Bollinger
April 1992,
Transplantation proceedings,
Y Yamaguchi, and
E C Halperin, and
R C Harland, and
C Wyble, and
R R Bollinger
January 1992,
Transplantation,
