BIOMAT Database Logo BIOMAT Database Logo

Boys with undescended testes: endocrine, volumetric and morphometric studies on testicular function before and after orchidopexy at nine months or three years of age. 2012

C Kollin, and J B Stukenborg, and M Nurmio, and E Sundqvist, and T Gustafsson, and O Söder, and J Toppari, and A Nordenskjöld, and E M Ritzén
Department of Women's and Children's Health, Pediatric Surgery Unit, Karolinska Institutet and University Hospital, Q2:08, SE-17176 Stockholm, Sweden. claude.kollin@karolinska.se

BACKGROUND A randomized controlled study was conducted comparing the outcome of surgery for congenital cryptorchidism at 9 months or 3 yr of age. OBJECTIVE The aim of the study was to investigate whether surgery at 9 months is more beneficial than at 3 yr and to identify early endocrine markers of importance for testicular development. METHODS A total of 213 biopsies were taken at orchidopexy, and the number of germ and Sertoli cells per 100 seminiferous cord cross-sections and the surface area of seminiferous tubules and interstitial tissue were analyzed. Inhibin B, FSH, LH, and testosterone were determined. Testicular volume was assessed by ultrasonography and by a ruler. RESULTS The number of germ and Sertoli cells and testicular volume at 9 months were significantly larger than at 3 yr. The intraabdominal testes showed the largest germ cell depletion at 3 yr. At both ages, testicular volume correlated to the number of germ and Sertoli cells. None of the hormones measured during the first 6 months of life (LH, FSH, testosterone, and inhibin B) could predict the number of germ or Sertoli cells at either 9 or 36 months of age, nor could hormone levels predict whether spontaneous descent would occur or not. CONCLUSIONS Morphometric and volumetric data show that orchidopexy at 9 months is more beneficial for testicular development than an operation at 3 yr of age. Testicular volume was furthermore shown to reflect germ cell numbers in early childhood, whereas endocrine parameters could not predict cellular structure of the testis or its spontaneous descent.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007265 Inhibins Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectively Female Inhibin,Inhibin,Inhibin-F,Inhibins, Female,Inhibins, Testicular,Ovarian Inhibin,Testicular Inhibin,Female Inhibins,Inhibin F,Inhibin, Female,Inhibin, Ovarian,Inhibin, Testicular,Testicular Inhibins
D007986 Luteinizing Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity. ICSH (Interstitial Cell Stimulating Hormone),Interstitial Cell-Stimulating Hormone,LH (Luteinizing Hormone),Lutropin,Luteoziman,Luteozyman,Hormone, Interstitial Cell-Stimulating,Hormone, Luteinizing,Interstitial Cell Stimulating Hormone
D008297 Male Males
D009929 Organ Size The measurement of an organ in volume, mass, or heaviness. Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D003456 Cryptorchidism A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis. Testis, Undescended,Abdominal Cryptorchidism,Bilateral Cryptorchidism,Cryptorchidism, Unilateral Or Bilateral,Cryptorchism,Inguinal Cryptorchidism,Testes, Undescended,Undescended Testis,Unilateral Cryptorchidism,Cryptorchidism, Abdominal,Cryptorchidism, Bilateral,Cryptorchidism, Inguinal,Cryptorchidism, Unilateral,Undescended Testes
D005640 Follicle Stimulating Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity. FSH (Follicle Stimulating Hormone),Follicle-Stimulating Hormone,Follitropin
D006728 Hormones Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects. Hormone,Hormone Receptor Agonists,Agonists, Hormone Receptor,Receptor Agonists, Hormone

Related Publications

C Kollin, and J B Stukenborg, and M Nurmio, and E Sundqvist, and T Gustafsson, and O Söder, and J Toppari, and A Nordenskjöld, and E M Ritzén
Surgical treatment of unilaterally undescended testes: testicular growth after randomization to orchiopexy at age 9 months or 3 years.
October 2007, The Journal of urology,
C Kollin, and J B Stukenborg, and M Nurmio, and E Sundqvist, and T Gustafsson, and O Söder, and J Toppari, and A Nordenskjöld, and E M Ritzén
ABC of urology. Orchidopexy before age of 10 is best for undescended testes.
August 1996, BMJ (Clinical research ed.),
C Kollin, and J B Stukenborg, and M Nurmio, and E Sundqvist, and T Gustafsson, and O Söder, and J Toppari, and A Nordenskjöld, and E M Ritzén
Orchidopexy at or after seven years of age.
January 1989, Lancet (London, England),
C Kollin, and J B Stukenborg, and M Nurmio, and E Sundqvist, and T Gustafsson, and O Söder, and J Toppari, and A Nordenskjöld, and E M Ritzén
Orchidopexy at or after seven years of age.
January 1989, Lancet (London, England),
C Kollin, and J B Stukenborg, and M Nurmio, and E Sundqvist, and T Gustafsson, and O Söder, and J Toppari, and A Nordenskjöld, and E M Ritzén
Testicular growth from birth to two years of age, and the effect of orchidopexy at age nine months: a randomized, controlled study.
March 2006, Acta paediatrica (Oslo, Norway : 1992),
C Kollin, and J B Stukenborg, and M Nurmio, and E Sundqvist, and T Gustafsson, and O Söder, and J Toppari, and A Nordenskjöld, and E M Ritzén
Testicular microlithiasis in acquired undescended testis after orchidopexy at diagnosis.
November 2013, Andrology,
C Kollin, and J B Stukenborg, and M Nurmio, and E Sundqvist, and T Gustafsson, and O Söder, and J Toppari, and A Nordenskjöld, and E M Ritzén
Gonadal Function in Boys with Bilateral Undescended Testes.
January 2024, Journal of the Endocrine Society,
C Kollin, and J B Stukenborg, and M Nurmio, and E Sundqvist, and T Gustafsson, and O Söder, and J Toppari, and A Nordenskjöld, and E M Ritzén
The role of ultrasound in the management of undescended testes before and after orchidopexy - an update.
December 2016, Medicine,
C Kollin, and J B Stukenborg, and M Nurmio, and E Sundqvist, and T Gustafsson, and O Söder, and J Toppari, and A Nordenskjöld, and E M Ritzén
[Morphological structure of undescended testis before and after orchidopexy].
December 1969, Klinicheskaia khirurgiia,
C Kollin, and J B Stukenborg, and M Nurmio, and E Sundqvist, and T Gustafsson, and O Söder, and J Toppari, and A Nordenskjöld, and E M Ritzén
Fertility after correction of bilateral undescended testes at the age of 23 years.
April 1993, British journal of urology,
Copied contents to your clipboard!