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Effect of heavy metal cations on the activity of cathepsin D (in vitro study). 2012
Alicja Karwowska, and
Radosław Łapiński, and
Marek Gacko, and
Ewa Grzegorczyk, and
Joanna Żurawska, and
Jan K Karczewski
Department of Hygiene and Epidemiology, Medical University of Bialystok, Poland. alicja.karwowska@umb.edu.pl
We studied the effect of heavy metal cations: Fe²⁺, Cu²⁺, Zn²⁺, Cd²⁺, Hg²⁺, Pb²⁺ on the activity of cathepsin D in human aorta homogenate and blood serum. The concentration of cations was 1 mmol/l. Hemoglobin was the cathepsin D substrate. The activity of cathepsin D was determined at pH 3.5. Only Hg²⁺ cations inhibit the activity of cathepsin D. Cations Hg²⁺ damage lysosomes and release cathepsin D from these organelles.
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