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A model of bronchial hyperreactivity at various times after an active anaphylactic shock in conscious guinea pigs is described. The bronchial inflammation was quantified in parallel by determination of the number of mononuclear cells, neutrophils, and eosinophils in bronchoalveolar lavage (BAL) fluids. The guinea pigs were sensitized by an intramuscular (i.m.) injection of a large dose of ovalbumin in Freund's complete adjuvant. The administration of ovalbumin (to induce anaphylactic shock) and of histamine to investigate bronchial hyperreactivity was by aerosol. The bronchial hyperreactivity to histamine was observed 3-6 hr after the anaphylactic shock. In the BAL fluid a decrease (1-3 hr) and then an increase (24-48 hr) in the number of mononuclear cells was found as well as an increase in neutrophils (3-48 hr) and in eosinophils (6-48 hr). The hyperreactivity was not correlated with changes in one category of cell in the BAL fluid. This model constitutes one simple test for investigating bronchial hyperreactivity in conscious guinea pigs. Further work is needed to try to determine the possible inflammatory parameters responsible for the hyperreactivity.
J P Tarayre, and
M Aliaga, and
M Barbara, and
N Tisseyre, and
S Vieu, and
J Tisne-Versailles
February 1989,
European journal of pharmacology,
J P Tarayre, and
M Aliaga, and
M Barbara, and
N Tisseyre, and
S Vieu, and
J Tisne-Versailles
January 1965,
International archives of allergy and applied immunology,
J P Tarayre, and
M Aliaga, and
M Barbara, and
N Tisseyre, and
S Vieu, and
J Tisne-Versailles
July 1988,
British journal of pharmacology,
J P Tarayre, and
M Aliaga, and
M Barbara, and
N Tisseyre, and
S Vieu, and
J Tisne-Versailles
October 1986,
Biulleten' eksperimental'noi biologii i meditsiny,
J P Tarayre, and
M Aliaga, and
M Barbara, and
N Tisseyre, and
S Vieu, and
J Tisne-Versailles
December 1965,
Archives internationales de physiologie et de biochimie,
J P Tarayre, and
M Aliaga, and
M Barbara, and
N Tisseyre, and
S Vieu, and
J Tisne-Versailles
December 1988,
Experientia,
J P Tarayre, and
M Aliaga, and
M Barbara, and
N Tisseyre, and
S Vieu, and
J Tisne-Versailles
January 1949,
Zeitschrift fur Hygiene und Infektionskrankheiten; medizinische Mikrobiologie, Immunologie und Virologie,
J P Tarayre, and
M Aliaga, and
M Barbara, and
N Tisseyre, and
S Vieu, and
J Tisne-Versailles
January 1971,
Naunyn-Schmiedebergs Archiv fur Pharmakologie,
J P Tarayre, and
M Aliaga, and
M Barbara, and
N Tisseyre, and
S Vieu, and
J Tisne-Versailles
June 1956,
Science (New York, N.Y.),
J P Tarayre, and
M Aliaga, and
M Barbara, and
N Tisseyre, and
S Vieu, and
J Tisne-Versailles
January 1935,
The Journal of experimental medicine,
