BIOMAT Database Logo BIOMAT Database Logo

Pulpal and periodontal diseases increase triglyceride levels in diabetic rats. 2013

Luciano Tavares Angelo Cintra, and Aguinaldo Cândido da Silva Facundo, and Mariane Maffei Azuma, and Dóris Hissako Sumida, and Rafael Dias Astolphi, and Suely Regina Mogami Bomfim, and Luís Gustavo Narciso, and João Eduardo Gomes-Filho
Endodontics, Araçatuba Dental School, UNESP-Univ Estadual Paulista, R. José Bonifácio, Araçatuba, 1193, São Paulo, Brazil. lucianocintra@foa.unesp.br

OBJECTIVE The aim of this study was to evaluate triglyceride and cholesterol levels in diabetic rats and their relationship with pulpal and periodontal diseases. METHODS Eighty male rats (Rattus norvegicus albinus, Wistar) were divided into the following eight groups comprising ten animals each: normal rats (G1), rats with pulpal diseases (G2), rats with periodontal diseases (G3), rats with both pulpal and periodontal diseases (G4), diabetic rats (G5), diabetic rats with pulpal diseases (G6), diabetic rats with periodontal diseases (G7), and diabetic rats with both periodontal and pulpal diseases (G8). Diabetes was induced by injecting streptozotocin, periapical lesions were induced by exposing pulpal tissue to the oral environment, and periodontal diseases were induced by periodontal ligature. The animals were killed after 30 days, and lipid profile was enzymatically measured using Trinder's method. The total assessed values were statistically analyzed by analysis of variance and Tukey test (p < 0.05). RESULTS The triglyceride levels of diabetic rats with periodontal disease and of diabetic rats with both periodontal and pulpal diseases were significantly higher than those of normal rats and nondiabetic group rats, respectively. The differences in the cholesterol levels among the groups were not significant. CONCLUSIONS We found that the association of pulpal and periodontal diseases with diabetes increased triglyceride levels in rats. CONCLUSIONS Changes in lipid profile may be related to the presence of oral infections and diabetes.

UI MeSH Term Description Entries
D008297 Male Males
D010483 Periapical Diseases Diseases of the PERIAPICAL TISSUE surrounding the root of the tooth, which is distinguished from DENTAL PULP DISEASES inside the TOOTH ROOT. Disease, Periapical,Diseases, Periapical,Periapical Disease
D010510 Periodontal Diseases Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT. Parodontosis,Pyorrhea Alveolaris,Disease, Periodontal,Diseases, Periodontal,Parodontoses,Periodontal Disease
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D002784 Cholesterol The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Epicholesterol
D003788 Dental Pulp Diseases Endodontic diseases of the DENTAL PULP inside the tooth, which is distinguished from PERIAPICAL DISEASES of the tissue surrounding the root. Dental Pulp Disease,Disease, Dental Pulp,Diseases, Dental Pulp,Pulp Disease, Dental,Pulp Diseases, Dental
D003789 Dental Pulp Exposure The result of pathological changes in the hard tissue of a tooth caused by carious lesions, mechanical factors, or trauma, which render the pulp susceptible to bacterial invasion from the external environment. Exposure, Dental Pulp,Pulp Exposure, Dental
D003921 Diabetes Mellitus, Experimental Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY. Alloxan Diabetes,Streptozocin Diabetes,Streptozotocin Diabetes,Experimental Diabetes Mellitus,Diabete, Streptozocin,Diabetes, Alloxan,Diabetes, Streptozocin,Diabetes, Streptozotocin,Streptozocin Diabete
D006943 Hyperglycemia Abnormally high BLOOD GLUCOSE level. Postprandial Hyperglycemia,Hyperglycemia, Postprandial,Hyperglycemias,Hyperglycemias, Postprandial,Postprandial Hyperglycemias

Related Publications

Luciano Tavares Angelo Cintra, and Aguinaldo Cândido da Silva Facundo, and Mariane Maffei Azuma, and Dóris Hissako Sumida, and Rafael Dias Astolphi, and Suely Regina Mogami Bomfim, and Luís Gustavo Narciso, and João Eduardo Gomes-Filho
Apical periodontitis and periodontal disease increase serum IL-17 levels in normoglycemic and diabetic rats.
December 2014, Clinical oral investigations,
Luciano Tavares Angelo Cintra, and Aguinaldo Cândido da Silva Facundo, and Mariane Maffei Azuma, and Dóris Hissako Sumida, and Rafael Dias Astolphi, and Suely Regina Mogami Bomfim, and Luís Gustavo Narciso, and João Eduardo Gomes-Filho
[Pulpal-periodontal diseases, endodontic therapy and influenza epidemics].
January 1977, Stomatologie der DDR,
Luciano Tavares Angelo Cintra, and Aguinaldo Cândido da Silva Facundo, and Mariane Maffei Azuma, and Dóris Hissako Sumida, and Rafael Dias Astolphi, and Suely Regina Mogami Bomfim, and Luís Gustavo Narciso, and João Eduardo Gomes-Filho
Risperidone-associated increase in triglyceride levels.
January 2009, The American journal of psychiatry,
Luciano Tavares Angelo Cintra, and Aguinaldo Cândido da Silva Facundo, and Mariane Maffei Azuma, and Dóris Hissako Sumida, and Rafael Dias Astolphi, and Suely Regina Mogami Bomfim, and Luís Gustavo Narciso, and João Eduardo Gomes-Filho
[Pulpal and periodontal symptomatology].
January 1971, La Revue stomato-odontologique du nord de la France,
Luciano Tavares Angelo Cintra, and Aguinaldo Cândido da Silva Facundo, and Mariane Maffei Azuma, and Dóris Hissako Sumida, and Rafael Dias Astolphi, and Suely Regina Mogami Bomfim, and Luís Gustavo Narciso, and João Eduardo Gomes-Filho
Relationship between blood triglyceride levels and periodontal status.
March 2004, Community dental health,
Luciano Tavares Angelo Cintra, and Aguinaldo Cândido da Silva Facundo, and Mariane Maffei Azuma, and Dóris Hissako Sumida, and Rafael Dias Astolphi, and Suely Regina Mogami Bomfim, and Luís Gustavo Narciso, and João Eduardo Gomes-Filho
[Pulpal calcifications related to cases of generalized periodontal diseases].
January 1978, Revista brasileira de odontologia,
Luciano Tavares Angelo Cintra, and Aguinaldo Cândido da Silva Facundo, and Mariane Maffei Azuma, and Dóris Hissako Sumida, and Rafael Dias Astolphi, and Suely Regina Mogami Bomfim, and Luís Gustavo Narciso, and João Eduardo Gomes-Filho
Pulpal periodontal disease.
September 1977, Journal of periodontology,
Luciano Tavares Angelo Cintra, and Aguinaldo Cândido da Silva Facundo, and Mariane Maffei Azuma, and Dóris Hissako Sumida, and Rafael Dias Astolphi, and Suely Regina Mogami Bomfim, and Luís Gustavo Narciso, and João Eduardo Gomes-Filho
[Pulpal-periodontal lesions].
January 1979, Ligament,
Luciano Tavares Angelo Cintra, and Aguinaldo Cândido da Silva Facundo, and Mariane Maffei Azuma, and Dóris Hissako Sumida, and Rafael Dias Astolphi, and Suely Regina Mogami Bomfim, and Luís Gustavo Narciso, and João Eduardo Gomes-Filho
Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion.
February 1995, Kidney international,
Luciano Tavares Angelo Cintra, and Aguinaldo Cândido da Silva Facundo, and Mariane Maffei Azuma, and Dóris Hissako Sumida, and Rafael Dias Astolphi, and Suely Regina Mogami Bomfim, and Luís Gustavo Narciso, and João Eduardo Gomes-Filho
High triglyceride levels increase the risk of diabetic microvascular complications: a cross-sectional study.
July 2023, Lipids in health and disease,
Copied contents to your clipboard!